Gene infA from Helicobacter pylori 26695: translation initiation factor IF-1
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Member of NCBI Protein Clusters
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PRK00276(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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900216
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UniProtKB accession
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RefSeq Protein accession
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NP_208090.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: infA
- locus tag: HP1298
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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other hits with E-value < 1e-05
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 7 genes click here
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GO terms
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CC:
GO:0005737 : cytoplasm : IEA
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MF:
GO:0003743 : translation initiation factor activity : IEA
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BP:
GO:0006413 : translational initiation : IEA
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BP:
GO:0006412 : translation : IEA
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MF:
GO:0003723 : RNA binding : IEA
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Domain Structure from CDD
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- S1_IF1: S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the formation of the first peptide bond. In Escherichia coli, the initiation mechanism requires, in addition to mRNA, fMet-tRNA, and ribosomal subunits, the presence of three additional proteins (initiation factors IF1, IF2, and IF3) and at least one GTP molecule. The three initiation factors influence both the kinetics and the stability of ternary complex formation. IF1 is the smallest of the three factors. IF1 enhances the rate of 70S ribosome subunit association and dissociation and the interaction of 30S ribosomal subunit with IF2 and IF3. It stimulates 30S complex formation. In addition, by binding to the A-site of the 30S ribosomal subunit, IF1 may contribute to the fidelity of the selection of the initiation site of the mRNA..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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| | HP1299 | methionine aminopeptidase | | | | secY | preprotein translocase subunit SecY | | | | rpsM | 30S ribosomal protein S13 | | | | rpmJ | 50S ribosomal protein L36 | | |
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| Phenotype |
Description |
Expression
Class |
Reference(s) |
| Candidate essential gene |
Identified as essential gene in one or more studies (see references) |
Knock out |
(candidate essential)
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