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Gene pyrE from Helicobacter pylori 26695: orotate phosphoribosyltransferase
Member of NCBI Protein Clusters PRK00455(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 900320
UniProtKB accession
RefSeq Protein accession NP_208049.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: pyrE
  • locus tag: HP1257
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction orotate phosphoribosyltransferase
Prof. Vitkup / Confidence:0.913 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0016208 AMP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004590 orotidine-5'-phosphate decarboxylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004588 orotate phosphoribosyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group Orotate phosphoribosyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group Orotidine-5'-phosphate decarboxylase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003999 adenine phosphoribosyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green gpt from Escherichia coli str. K-12 substr. MG1655

to see the rest 22 genes click here
GO terms
  • MF: GO:0016757 : transferase activity, transferring glycosyl groups : IEA
  • MF: GO:0004588 : orotate phosphoribosyltransferase activity : IEA
  • BP: GO:0019856 : pyrimidine base biosynthetic process : IEA
  • BP: GO:0009116 : nucleoside metabolic process : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0006221 : pyrimidine nucleotide biosynthetic process : IEA
Domain Structure from CDD
  • Pribosyltran: Phosphoribosyl transferase domain. hypoxanthine phosphoribosyltransferase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP1258hypothetical protein
HP1259hypothetical protein
secGpreprotein translocase subunit SecG
frrribosome recycling factor
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ORPT

orotate phosphoribosyltransferase
orot5p[c] + ppi[c] <=> orot[c] + prpp[c]
UTP/CTP de novo Synthesis

Source: Ported to COMBREX by Segre's Lab