Gene pyrE from Helicobacter pylori 26695: orotate phosphoribosyltransferase
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Member of NCBI Protein Clusters
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PRK00455(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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900320
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UniProtKB accession
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RefSeq Protein accession
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NP_208049.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: pyrE
- locus tag: HP1257
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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EC number
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BLASTP hits to experimentally validated proteins
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This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 22 genes click here
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GO terms
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MF:
GO:0016757 : transferase activity, transferring glycosyl groups : IEA
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MF:
GO:0004588 : orotate phosphoribosyltransferase activity : IEA
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BP:
GO:0019856 : pyrimidine base biosynthetic process : IEA
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BP:
GO:0009116 : nucleoside metabolic process : IEA
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MF:
GO:0016740 : transferase activity : IEA
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BP:
GO:0006221 : pyrimidine nucleotide biosynthetic process : IEA
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Domain Structure from CDD
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- Pribosyltran: Phosphoribosyl transferase domain. hypoxanthine phosphoribosyltransferase; Provisional
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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 | | HP1258 | hypothetical protein | | | HP1259 | hypothetical protein | | | secG | preprotein translocase subunit SecG | | | frr | ribosome recycling factor | |
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Metabolic Annotation from Palsson Lab
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Metabolic Reaction: ORPT
- Name
- orotate phosphoribosyltransferase
- Formula
- orot5p[c] + ppi[c] <=> orot[c] + prpp[c]
- Pathway
- UTP/CTP de novo Synthesis
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KEGG
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