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Gene ftsI from Escherichia coli str. K-12 substr. MG1655: transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)
Member of NCBI Protein Clusters CLSK879555(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 944799
UniProtKB accession
RefSeq Protein accession NP_414626.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ftsI
  • locus tag: b0084
  • aliases: ECK0085, JW0082, pbpB, sep
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10341
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)
Source References Functional description
GSDB
[PMID: 3911028]
[PMID: 2681146]
[PMID: 3049550]
[PMID: 2677607]
Peptidoglycan synthase ftsI (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number 2.4.1.129 (See reaction via BRENDA)) (Source: BRENDA)
GO terms
  • CC: GO:0005887 : integral to plasma membrane : IDA
  • BP: GO:0007049 : cell cycle : IEA
  • BP: GO:0046677 : response to antibiotic : IEA
  • MF: GO:0008955 : peptidoglycan glycosyltransferase activity : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • MF: GO:0008658 : penicillin binding : IDA
  • MF: GO:0008955 : peptidoglycan glycosyltransferase activity : IMP
  • BP: GO:0007047 : cellular cell wall organization : IEA
  • BP: GO:0042493 : response to drug : IMP
  • BP: GO:0009273 : peptidoglycan-based cell wall biogenesis : IEA
  • MF: GO:0005515 : protein binding : IGI
  • CC: GO:0031226 : intrinsic to plasma membrane : IDA
  • MF: GO:0016740 : transferase activity : IEA
  • MF: GO:0016757 : transferase activity, transferring glycosyl groups : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0008658 : penicillin binding : IEA
  • MF: GO:0008955 : peptidoglycan glycosyltransferase activity : IDA
  • CC: GO:0016021 : integral to membrane : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • BP: GO:0042493 : response to drug : IDA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • BP: GO:0051301 : cell division : IMP
  • CC: GO:0032155 : cell division site part : IDA
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0051301 : cell division : IEA
Domain Structure from CDD
  • PBP_dimer: Penicillin-binding Protein dimerization domain. This domain is found at the N terminus of Class B High Molecular Weight .... (More)
  • Transpeptidase: Penicillin binding protein transpeptidase domain. Beta-lactamase class D [Defense mechanisms]
  • FtsI: Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03291 , EcolC_3573 , ECP_0086 , ECSE_0086 , Ent638_0630 , ESA_03254 , ftsI (49) , NT01EI_0730 , SARI_02879 , SG0443 , SPAB_00156 , Spro_0755 , SSPA0120 , YPA_3552 , YpAngola_A2924 , YPDSF_3093 , YPK_3524 , YPN_0415 , YpsIP31758_3393 , YPTS_0709
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
gene neighbourhoods
domain fusion
radADNA repair protein
 
  
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-dia
 
 
 
ftsLmembrane bound cell division protein at septum con 
 
 
mfdtranscription-repair coupling factor
 
  
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
  
rsuA16S rRNA U516 pseudouridine synthase
 
  
yggWpredicted oxidoreductase, HemN family
 
  
cusRDNA-binding response regulator in two-component re
 
  
secGpreprotein translocase membrane subunit
 
  
yebApredicted peptidase
 
  
ygeRnovel lipoprotein, function unknown
 
  
ddlBD-alanine:D-alanine ligase
 
  
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t
 
  
mrdBcell wall shape-determining protein
 
  
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
 
  
rpsA30S ribosomal subunit protein S1
 
  
kdpEDNA-binding response regulator in two-component re
 
  
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
  
prfBpeptide chain release factor RF-2
 
  
baeRDNA-binding response regulator in two-component re
 
  
ftsWintegral membrane protein involved in stabilizing
 
  
rluE23S rRNA U2457 pseudouridine synthase
 
  
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
 
  
murGN-acetylglucosaminyl transferase
 
  
phoBDNA-binding response regulator in two-component re
 
  
ompRDNA-binding response regulator in two-component re
 
  
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
 
  
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho
 
  
qseBquorum sensing DNA-binding response regulator in t
 
  
pnppolynucleotide phosphorylase/polyadenylase
 
  
recGATP-dependent DNA helicase
 
  
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
  
torRDNA-binding response regulator in two-component re
 
  
rluF23S rRNA U2604 pseudouridine synthase
 
  
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
 
  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
  
ddlAD-alanine-D-alanine ligase A
 
  
yedWpredicted DNA-binding response regulator in two-co
 
  
nlpDnovel lipoprotein, function unknown
 
  
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
  
priAPrimosome factor n' (replication factor Y)
 
  
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
  
pcnBpoly(A) polymerase I
 
  
yaeJconserved protein
 
  
murCUDP-N-acetylmuramate:L-alanine ligase
 
  
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
  
rimM16S rRNA processing protein
 
  
phoPDNA-binding response regulator in two-component re
 
  
arcADNA-binding response regulator in two-component re
 
  
yajCSecYEG protein translocase auxillary subunit
 
  
creBDNA-binding response regulator in two-component re
 
  
rluB23S rRNA pseudouridylate synthase
 
  
cpxRDNA-binding response regulator in two-component re
 
  
basRDNA-binding response regulator in two-component re
 
  
mtgAbiosynthetic peptidoglycan transglycosylase  
 
mrcAfused penicillin-binding protein 1a: murein transg  
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)