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Gene bcr from Escherichia coli str. K-12 substr. MG1655: bicyclomycin/multidrug efflux system
Member of NCBI Protein Clusters PRK11102(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 944808
UniProtKB accession
RefSeq Protein accession NP_416687.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: bcr
  • locus tag: b2182
  • aliases: ECK2176, JW5363, bicA, bicR, sur, suxA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11419
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Source Predicted function(s)
NCBI Protein Cluster Prediction bicyclomycin/multidrug efflux system
Source References Functional description
GSDB Under Review bicyclomycin resistance protein (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0015238 : drug transmembrane transporter activity : IEA
  • BP: GO:0015893 : drug transport : IEA
  • BP: GO:0006810 : transport : IEA
  • BP: GO:0046677 : response to antibiotic : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • BP: GO:0055085 : transmembrane transport : IEA
  • MF: GO:0005215 : transporter activity : IEA
  • CC: GO:0016020 : membrane : IEA
Domain Structure from CDD
  • MFS: The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters,.... (More)
  • PRK11102: bicyclomycin/multidrug efflux system; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
bcr (38) , CKO_00594 , EcolC_1465 , ECP_2223 , ECs3074 , ECSE_2451 , Ent638_2778 , ESA_01055 , SARI_00666 , SPAB_00779 , SSPA0590
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rsuA16S rRNA U516 pseudouridine synthase
coaEdephospho-CoA kinase 
Phenotype Description Expression
Antibiotic resistance class bcr Wild type
PMID: 16397293
PMID: 9278503
PMID: 2570347