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Gene cusR from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with CusS
Member of NCBI Protein Clusters PRK09836(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945003
UniProtKB accession
RefSeq Protein accession NP_415103.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: cusR
  • locus tag: b0571
  • aliases: ECK0563, JW0560, silR, ylcA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: G6319
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional activator CusR
Source References Functional description
GSDB Under Review transcriptional regulatory protein CusR (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • MF: GO:0005507 : copper ion binding : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0007600 : sensory perception : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • PRK09836: DNA-binding transcriptional activator CusR; Provisional
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_02615 , cusR (18) , EcolC_3075 , EcolC_3426 , ECP_0602 , ECs0609 , ECSE_0635 , ESA_04238 , KP1_0690 , KPN_04740 , NT01EI_2120 , pK2044_00635 , Shewana3_4296 , silR (5) , Sputcn32_0258 , ylcA (7)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 domain fusion
gene neighbourhoods
phylogenetic profile
ydeHdiguanylate cyclase, required for pgaD induction
cusSsensory histidine kinase in two-component regulato 
mfdtranscription-repair coupling factor  
murCUDP-N-acetylmuramate:L-alanine ligase  
recNrecombination and repair protein  
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP  
fabB3-oxoacyl-[acyl-carrier-protein] synthase I  
ftsItranspeptidase involved in septal peptidoglycan sy  
accAacetyl-CoA carboxylase, carboxytransferase, alpha   
fabF3-oxoacyl-[acyl-carrier-protein] synthase II  
ddlBD-alanine:D-alanine ligase  
radADNA repair protein  
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase  
rsuA16S rRNA U516 pseudouridine synthase  
xseAexonuclease VII, large subunit  
mrdBcell wall shape-determining protein  
rluE23S rRNA U2457 pseudouridine synthase  
ftsWintegral membrane protein involved in stabilizing   
recRgap repair protein  
mrdAtranspeptidase involved in peptidoglycan synthesis  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex  
ddlAD-alanine-D-alanine ligase A  
fabH3-oxoacyl-[acyl-carrier-protein] synthase III  
usgpredicted semialdehyde dehydrogenase  
clpXATPase and specificity subunit of ClpX-ClpP ATP-de  
recGATP-dependent DNA helicase  
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans  
rluF23S rRNA U2604 pseudouridine synthase  
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p  
accCacetyl-CoA carboxylase, biotin carboxylase subunit  
xseBexonuclease VII small subunit  
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD  
priAPrimosome factor n' (replication factor Y)  
rluB23S rRNA pseudouridylate synthase  
dhaRDNA-binding transcription activator of the dhaKLM
yfiNpredicted diguanylate cyclase
ycdTdiguanylate cyclase
yedQpredicted diguanylate cyclase
adrAdiguanylate cyclase for cellulose, biofilm, motili
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re
rtcRsigma 54-dependent transcriptional regulator of rt
yliFpredicted diguanylate cyclase
yeaIpredicted diguanylate cyclase
prpRpropionate catabolism operon regulatory protein
fhlADNA-binding transcriptional activator
pspFDNA-binding transcriptional activator
ydaMdiguanylate cyclase, csgD regulator
hyfRDNA-binding transcriptional activator, formate sen
yeaPdiguanylate cyclase
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m
yegEpredicted diguanylate cyclase, GGDEF domain signal
yeaJpredicted diguanylate cyclase
dosCdiguanylate cyclase
norRAnaerobic nitric oxide reductase DNA-binding trans
yhjKpredicted diguanylate cyclase
yneFpredicted diguanylate cyclase
ygeVpredicted DNA-binding transcriptional regulator