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Gene clpP from Escherichia coli str. K-12 substr. MG1655: proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases
Member of NCBI Protein Clusters PRK00277(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945082
UniProtKB accession
RefSeq Protein accession NP_414971.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: clpP
  • locus tag: b0437
  • aliases: ECK0431, JW0427, lopP, wseA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction ATP-dependent Clp protease proteolytic subunit
Source References Functional description
[PMID: 2197275]
[PMID: 8407953]
[PMID: 8831780]
[PMID: 9390554]
ATP-dependent Clp protease proteolytic subunit (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0008236 : serine-type peptidase activity : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • CC: GO:0005829 : cytosol : IDA
  • BP: GO:0006515 : misfolded or incompletely synthesized protein catabolic process : IDA
  • CC: GO:0005624 : membrane fraction : IDA
  • BP: GO:0006508 : proteolysis : IEA
  • MF: GO:0004252 : serine-type endopeptidase activity : IEA
  • CC: GO:0016020 : membrane : IDA
  • BP: GO:0009408 : response to heat : IEP
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0008233 : peptidase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • BP: GO:0006950 : response to stress : IEA
Domain Structure from CDD
  • S14_ClpP_2: Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease. Clp protease (caseinolytic protease;.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_02723 , clpP (63) , clpP2 , ESA_02861 , NT01EI_1078 , SARI_02486 , SPAB_03130 , Spro_1095
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
tigpeptidyl-prolyl cis/trans isomerase (trigger facto
rluE23S rRNA U2457 pseudouridine synthase 
mrdAtranspeptidase involved in peptidoglycan synthesis 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de 
murGN-acetylglucosaminyl transferase 
cusRDNA-binding response regulator in two-component re 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
mrdBcell wall shape-determining protein 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
phoBDNA-binding response regulator in two-component re 
ompRDNA-binding response regulator in two-component re 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
rimM16S rRNA processing protein 
qseBquorum sensing DNA-binding response regulator in t 
prfBpeptide chain release factor RF-2 
baeRDNA-binding response regulator in two-component re 
ftsWintegral membrane protein involved in stabilizing  
pnppolynucleotide phosphorylase/polyadenylase 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
torRDNA-binding response regulator in two-component re 
rluF23S rRNA U2604 pseudouridine synthase 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
yajCSecYEG protein translocase auxillary subunit 
ddlAD-alanine-D-alanine ligase A 
yedWpredicted DNA-binding response regulator in two-co 
yggWpredicted oxidoreductase, HemN family 
nlpDnovel lipoprotein, function unknown 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
pcnBpoly(A) polymerase I 
priAPrimosome factor n' (replication factor Y) 
secGpreprotein translocase membrane subunit 
yaeJconserved protein 
murCUDP-N-acetylmuramate:L-alanine ligase 
radADNA repair protein 
rluB23S rRNA pseudouridylate synthase 
ygeRnovel lipoprotein, function unknown 
basRDNA-binding response regulator in two-component re 
phoPDNA-binding response regulator in two-component re 
mfdtranscription-repair coupling factor 
yebApredicted peptidase 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
creBDNA-binding response regulator in two-component re 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
ddlBD-alanine:D-alanine ligase 
arcADNA-binding response regulator in two-component re 
rpsA30S ribosomal subunit protein S1 
kdpEDNA-binding response regulator in two-component re 
cpxRDNA-binding response regulator in two-component re