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Gene clpX from Escherichia coli str. K-12 substr. MG1655: ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease
Member of NCBI Protein Clusters PRK05342(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945083
UniProtKB accession
RefSeq Protein accession NP_414972.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: clpX
  • locus tag: b0438
  • aliases: ECK0432, JW0428, lopC
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction ATP-dependent protease ATP-binding subunit ClpX
Source References Functional description
[PMID: 8226769]
[PMID: 7743994]
[PMID: 14525985]
ATP-dependent Clp protease ATP-binding subunit ClpX (source organism: Escherichia coli (strain K12).; strain specific ID: K12 / W3110 / ATCC 27325 / DSM 5911)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006457 : protein folding : IEA
  • MF: GO:0051082 : unfolded protein binding : IEA
  • MF: GO:0008270 : zinc ion binding : IEA
  • BP: GO:0006950 : response to stress : IEA
  • BP: GO:0019538 : protein metabolic process : IEA
  • MF: GO:0017111 : nucleoside-triphosphatase activity : IEA
  • MF: GO:0016887 : ATPase activity : IEA
  • MF: GO:0046983 : protein dimerization activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD
  • clpX: ATP-dependent protease ATP-binding subunit ClpX; Provisional
  • zf-C4_ClpX: ClpX C4-type zinc finger. The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp10.... (More)
  • AAA: The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPa.... (More)
  • ClpB_D2-small: C-terminal, D2-small domain, of ClpB protein. This is the C-terminal domain of ClpB protein, referred to as the D2-small.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
clpX (99) , NT01EI_1080 , Tola_1084 , VCD_002441
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
lonDNA-binding ATP-dependent protease La
phoBDNA-binding response regulator in two-component re 
ompRDNA-binding response regulator in two-component re 
pnppolynucleotide phosphorylase/polyadenylase 
recGATP-dependent DNA helicase 
torRDNA-binding response regulator in two-component re 
rluF23S rRNA U2604 pseudouridine synthase 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
yedWpredicted DNA-binding response regulator in two-co 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
priAPrimosome factor n' (replication factor Y) 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
mrdBcell wall shape-determining protein 
yaeJconserved protein 
murCUDP-N-acetylmuramate:L-alanine ligase 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
rimM16S rRNA processing protein 
phoPDNA-binding response regulator in two-component re 
arcADNA-binding response regulator in two-component re 
prfBpeptide chain release factor RF-2 
baeRDNA-binding response regulator in two-component re 
ftsWintegral membrane protein involved in stabilizing  
creBDNA-binding response regulator in two-component re 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
ddlAD-alanine-D-alanine ligase A 
cpxRDNA-binding response regulator in two-component re 
rluB23S rRNA pseudouridylate synthase 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
ddlBD-alanine:D-alanine ligase 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
rsuA16S rRNA U516 pseudouridine synthase 
yggWpredicted oxidoreductase, HemN family 
cusRDNA-binding response regulator in two-component re 
ftsItranspeptidase involved in septal peptidoglycan sy 
pcnBpoly(A) polymerase I 
mfdtranscription-repair coupling factor 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
rluE23S rRNA U2457 pseudouridine synthase 
qseBquorum sensing DNA-binding response regulator in t 
rpsA30S ribosomal subunit protein S1 
kdpEDNA-binding response regulator in two-component re 
basRDNA-binding response regulator in two-component re 
mrdAtranspeptidase involved in peptidoglycan synthesis 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de