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Functional Status	Green (experimental evidence, uncurated)
GO terms	MF: GO:0046872 : metal ion binding : IEA MF: GO:0005524 : ATP binding : IEA BP: GO:0006457 : protein folding : IEA MF: GO:0051082 : unfolded protein binding : IEA MF: GO:0008270 : zinc ion binding : IEA BP: GO:0006950 : response to stress : IEA BP: GO:0019538 : protein metabolic process : IEA MF: GO:0017111 : nucleoside-triphosphatase activity : IEA MF: GO:0016887 : ATPase activity : IEA MF: GO:0046983 : protein dimerization activity : IEA MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD	clpX: ATP-dependent protease ATP-binding subunit ClpX; Provisional zf-C4_ClpX: ClpX C4-type zinc finger. The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins, and possesses a putative zinc finger motif of the C4 type. This presumed zinc binding domain is found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone. The molecular function of this domain is now known..... (More) AAA: The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases..... (More) ClpB_D2-small: C-terminal, D2-small domain, of ClpB protein. This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, pfam00004) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilize the functional assembly. The domain is associated with two Clp_N, pfam02861, at the N-terminus as well as AAA, pfam00004 and AAA_2, pfam07724..... (More) See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	zf-C4_ClpX AAA_2 H ClpB_D2-small H See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] clpX (99) , NT01EI_1080 , Tola_1084 , VCD_002441

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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

clpP proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP     lon DNA-binding ATP-dependent protease La     phoB DNA-binding response regulator in two-component re     ompR DNA-binding response regulator in two-component re     pnp polynucleotide phosphorylase/polyadenylase     recG ATP-dependent DNA helicase     torR DNA-binding response regulator in two-component re     rluF 23S rRNA U2604 pseudouridine synthase     rsmD 16S rRNA m(2)G966 methyltransferase, SAM-dependent     yedW predicted DNA-binding response regulator in two-co     murB UDP-N-acetylenolpyruvoylglucosamine reductase, FAD     priA Primosome factor n' (replication factor Y)     miaA delta(2)-isopentenylpyrophosphate tRNA-adenosine t     mrdB cell wall shape-determining protein     yaeJ conserved protein     murC UDP-N-acetylmuramate:L-alanine ligase     rstA multicopy supressor of yjeE, yeaZ or ygjD deletion     rimM 16S rRNA processing protein     phoP DNA-binding response regulator in two-component re     arcA DNA-binding response regulator in two-component re     prfB peptide chain release factor RF-2     baeR DNA-binding response regulator in two-component re     ftsW integral membrane protein involved in stabilizing     creB DNA-binding response regulator in two-component re     fabF 3-oxoacyl-[acyl-carrier-protein] synthase II     polA fused DNA polymerase I 5'->3' polymerase/3'->5' ex     ddlA D-alanine-D-alanine ligase A     cpxR DNA-binding response regulator in two-component re     rluB 23S rRNA pseudouridylate synthase     cca fused tRNA nucleotidyl transferase/2'3'-cyclic pho     ddlB D-alanine:D-alanine ligase     murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase     rsuA 16S rRNA U516 pseudouridine synthase     yggW predicted oxidoreductase, HemN family     cusR DNA-binding response regulator in two-component re     ftsI transpeptidase involved in septal peptidoglycan sy     pcnB poly(A) polymerase I     mfd transcription-repair coupling factor     fabB 3-oxoacyl-[acyl-carrier-protein] synthase I     rluE 23S rRNA U2457 pseudouridine synthase     qseB quorum sensing DNA-binding response regulator in t     rpsA 30S ribosomal subunit protein S1     kdpE DNA-binding response regulator in two-component re     mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes     basR DNA-binding response regulator in two-component re     mrdA transpeptidase involved in peptidoglycan synthesis     hemN coproporphyrinogen III oxidase, SAM and NAD(P)H de