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Gene mrdB from Escherichia coli str. K-12 substr. MG1655: cell wall shape-determining protein
Member of NCBI Protein Clusters PRK10794(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945238
UniProtKB accession
RefSeq Protein accession NP_415167.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: mrdB
  • locus tag: b0634
  • aliases: ECK0627, JW0629, rodA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10607
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction cell wall shape-determining protein
Source References Functional description
GSDB Under Review rod shape-determining protein rodA (source organism: Shigella flexneri; strain specific ID: NCBI_TaxID=623)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0008360 : regulation of cell shape : IMP
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
Domain Structure from CDD
  • FTSW_RODA_SPOVE: Cell cycle protein. cell wall shape-determining protein; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_02523 , EcolC_3011 , ECP_0664 , ECs0672 , ECSE_0702 , Ent638_1169 , ESA_02693 , ftsW1 , mrdB (48) , NT01EI_2943 , rodA (4) , SARI_02293 , SG0796 , SPAB_02913 , Spro_1200 , SSPA1947 , YPA_2494 , YPDSF_2650 , YPK_3022 , YPN_1088 , YPTS_1153
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
gene neighbourhoods
rluF23S rRNA U2604 pseudouridine synthase
 
 
rlpAseptal ring protein, suppressor of prc, minor lipo 
 
mrdAtranspeptidase involved in peptidoglycan synthesis
 
 
ompRDNA-binding response regulator in two-component re
 
 
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-dia
 
 
ddlBD-alanine:D-alanine ligase
 
 
baeRDNA-binding response regulator in two-component re
 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
 
creBDNA-binding response regulator in two-component re
 
 
basRDNA-binding response regulator in two-component re
 
 
yaeJconserved protein
 
 
ftsItranspeptidase involved in septal peptidoglycan sy
 
 
phoBDNA-binding response regulator in two-component re
 
 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t
 
 
qseBquorum sensing DNA-binding response regulator in t
 
 
prfBpeptide chain release factor RF-2
 
 
ygeRnovel lipoprotein, function unknown
 
 
torRDNA-binding response regulator in two-component re
 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
 
nlpDnovel lipoprotein, function unknown
 
 
murGN-acetylglucosaminyl transferase
 
 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
 
 
rluE23S rRNA U2457 pseudouridine synthase
 
 
pnppolynucleotide phosphorylase/polyadenylase
 
 
yajCSecYEG protein translocase auxillary subunit
 
 
cusRDNA-binding response regulator in two-component re
 
 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
 
 
rsuA16S rRNA U516 pseudouridine synthase
 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
 
radADNA repair protein
 
 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
 
 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
 
 
arcADNA-binding response regulator in two-component re
 
 
yebApredicted peptidase
 
 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho
 
 
yggWpredicted oxidoreductase, HemN family
 
 
rpsA30S ribosomal subunit protein S1
 
 
phoPDNA-binding response regulator in two-component re
 
 
secGpreprotein translocase membrane subunit
 
 
recGATP-dependent DNA helicase
 
 
ddlAD-alanine-D-alanine ligase A
 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
 
kdpEDNA-binding response regulator in two-component re
 
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
 
cpxRDNA-binding response regulator in two-component re
 
 
yedWpredicted DNA-binding response regulator in two-co
 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
 
rimM16S rRNA processing protein
 
 
mfdtranscription-repair coupling factor
 
 
rluB23S rRNA pseudouridylate synthase
 
 
pcnBpoly(A) polymerase I
 
 
priAPrimosome factor n' (replication factor Y)
 
 
murCUDP-N-acetylmuramate:L-alanine ligase
 
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)