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Gene mrdA from Escherichia coli str. K-12 substr. MG1655: transpeptidase involved in peptidoglycan synthesis (penicillin-binding protein 2)
Member of NCBI Protein Clusters PRK10795(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945240
UniProtKB accession
RefSeq Protein accession NP_415168.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: mrdA
  • locus tag: b0635
  • aliases: ECK0628, JW0630, pbpA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10606
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Source Predicted function(s)
NCBI Protein Cluster Prediction penicillin-binding protein 2
Source References Functional description
GSDB Under Review Penicillin-binding protein 2 (source organism: Escherichia coli (strain K12).; strain specific ID: K12)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0046677 : response to antibiotic : IMP
  • BP: GO:0046677 : response to antibiotic : IEA
  • BP: GO:0042493 : response to drug : IDA
  • MF: GO:0009002 : serine-type D-Ala-D-Ala carboxypeptidase activity : IDA
  • MF: GO:0004180 : carboxypeptidase activity : IDA
  • BP: GO:0008360 : regulation of cell shape : IMP
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • CC: GO:0005886 : plasma membrane : IDA
  • CC: GO:0019898 : extrinsic to membrane : IEA
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IMP
  • BP: GO:0007047 : cellular cell wall organization : IEA
  • BP: GO:0007047 : cellular cell wall organization : IMP
  • BP: GO:0009273 : peptidoglycan-based cell wall biogenesis : IEA
  • MF: GO:0008144 : drug binding : IDA
  • MF: GO:0003824 : catalytic activity : IEA
  • CC: GO:0031225 : anchored to membrane : IDA
  • MF: GO:0008658 : penicillin binding : IEA
  • MF: GO:0008658 : penicillin binding : IMP
  • CC: GO:0005886 : plasma membrane : IEA
Domain Structure from CDD
  • PBP_dimer: Penicillin-binding Protein dimerization domain. This domain is found at the N terminus of Class B High Molecular Weight .... (More)
  • PRK10795: penicillin-binding protein 2; Provisional
  • Transpeptidase: Penicillin binding protein transpeptidase domain. Beta-lactamase class D [Defense mechanisms]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_02522 , EcolC_3010 , ECP_0665 , ECs0673 , ECSE_0703 , Ent638_1170 , ESA_02692 , mrdA (42) , NT01EI_2942 , pbpA (8) , SARI_02292 , SG0797 , SPAB_02912 , Spro_1201 , SSPA1946 , YPA_2493 , YPDSF_2649 , YPK_3021 , YPN_1089 , YPTS_1154
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
rlmH23S rRNA m(3)Psi1915 pseudouridine methyltransfera
 
 
mrdBcell wall shape-determining protein
 
 
secGpreprotein translocase membrane subunit 
 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase 
 
murCUDP-N-acetylmuramate:L-alanine ligase 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
 
radADNA repair protein 
 
rluB23S rRNA pseudouridylate synthase 
 
ygeRnovel lipoprotein, function unknown 
 
basRDNA-binding response regulator in two-component re 
 
yaeJconserved protein 
 
phoPDNA-binding response regulator in two-component re 
 
mfdtranscription-repair coupling factor 
 
yebApredicted peptidase 
 
rluF23S rRNA U2604 pseudouridine synthase 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
 
murGN-acetylglucosaminyl transferase 
 
recGATP-dependent DNA helicase 
 
creBDNA-binding response regulator in two-component re 
 
rsuA16S rRNA U516 pseudouridine synthase 
 
priAPrimosome factor n' (replication factor Y) 
 
ddlBD-alanine:D-alanine ligase 
 
ompRDNA-binding response regulator in two-component re 
 
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-dia 
 
arcADNA-binding response regulator in two-component re 
 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
 
cpxRDNA-binding response regulator in two-component re 
 
phoBDNA-binding response regulator in two-component re 
 
torRDNA-binding response regulator in two-component re 
 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de 
 
rluE23S rRNA U2457 pseudouridine synthase 
 
prfBpeptide chain release factor RF-2 
 
baeRDNA-binding response regulator in two-component re 
 
ftsWintegral membrane protein involved in stabilizing  
 
cusRDNA-binding response regulator in two-component re 
 
yedWpredicted DNA-binding response regulator in two-co 
 
pnppolynucleotide phosphorylase/polyadenylase 
 
nlpDnovel lipoprotein, function unknown 
 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
 
rimM16S rRNA processing protein 
 
qseBquorum sensing DNA-binding response regulator in t 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
 
yajCSecYEG protein translocase auxillary subunit 
 
rpsA30S ribosomal subunit protein S1 
 
kdpEDNA-binding response regulator in two-component re 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes 
 
ddlAD-alanine-D-alanine ligase A 
 
yggWpredicted oxidoreductase, HemN family 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
 
pcnBpoly(A) polymerase I 
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)