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Gene kdpE from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with KdpD
Member of NCBI Protein Clusters PRK10529(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945302
UniProtKB accession
RefSeq Protein accession NP_415222.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: kdpE
  • locus tag: b0694
  • aliases: ECK0682, JW5096
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1ZH2 1ZH4 3ZQ7
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10517
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Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional activator KdpE
Source References Functional description
GSDB Under Review KDP operon transcriptional regulatory protein KdpE (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK10529: DNA-binding transcriptional activator KdpE; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_02467 , EcolC_2962 , ECP_0712 , ECs0722 , ECSE_0754 , Ent638_1206 , ESA_02645 , kdpE (34) , SARI_02239 , SeAg_B0750 , SeD_A0810 , SeHA_C0824 , SeSA_A0860 , SNSL254_A0763 , SPAB_02834 , SSPA1900
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
kdpDfused sensory histidine kinase in two-component re
 
 
rluB23S rRNA pseudouridylate synthase 
 
mfdtranscription-repair coupling factor 
 
rluF23S rRNA U2604 pseudouridine synthase 
 
recNrecombination and repair protein 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
 
recGATP-dependent DNA helicase 
 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
 
ftsItranspeptidase involved in septal peptidoglycan sy 
 
rsuA16S rRNA U516 pseudouridine synthase 
 
priAPrimosome factor n' (replication factor Y) 
 
ddlBD-alanine:D-alanine ligase 
 
rluE23S rRNA U2457 pseudouridine synthase 
 
xseAexonuclease VII, large subunit 
 
recRgap repair protein 
 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
 
mrdBcell wall shape-determining protein 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
 
ddlAD-alanine-D-alanine ligase A 
 
ftsWintegral membrane protein involved in stabilizing  
 
usgpredicted semialdehyde dehydrogenase 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
 
mrdAtranspeptidase involved in peptidoglycan synthesis 
 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
 
xseBexonuclease VII small subunit 
 
murCUDP-N-acetylmuramate:L-alanine ligase 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes 
 
radADNA repair protein