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Gene rpsA from Escherichia coli str. K-12 substr. MG1655: 30S ribosomal subunit protein S1
Member of NCBI Protein Clusters PRK06299(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945536
UniProtKB accession
RefSeq Protein accession NP_415431.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rpsA
  • locus tag: b0911
  • aliases: ECK0902, JW0894, ssyF
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 2BH8 2KHI 2KHJ
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10900
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 30S ribosomal protein S1
Source References Functional description
GSDB Under Review 30S ribosomal protein S1 (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • CC: GO:0030529 : ribonucleoprotein complex : IEA
  • BP: GO:0006412 : translation : IEA
  • CC: GO:0005737 : cytoplasm : IDA
  • CC: GO:0016020 : membrane : IDA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0003735 : structural constituent of ribosome : IEA
  • CC: GO:0005840 : ribosome : IEA
Domain Structure from CDD
  • S1_RPS1_repeat_ec3: S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be.... (More)
  • S1_RPS1_repeat_ec2_hs2: S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought t.... (More)
  • S1_RPS1_repeat_ec4: S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be.... (More)
  • rpsA: 30S ribosomal protein S1; Reviewed
  • S1_RPS1_repeat_ec6: S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be.... (More)
  • S1_RPS1_repeat_ec5: S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
NT01EI_2455 , rpsA (108) , Tola_1557 , VCD_002447
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
domain fusion
cmkcytidylate kinase
ihfBintegration host factor (IHF), DNA-binding protein
rluB23S rRNA pseudouridylate synthase 
yaeJconserved protein 
rluF23S rRNA U2604 pseudouridine synthase 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
priAPrimosome factor n' (replication factor Y) 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
rluE23S rRNA U2457 pseudouridine synthase 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
mrdBcell wall shape-determining protein 
pnppolynucleotide phosphorylase/polyadenylase 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
prfBpeptide chain release factor RF-2 
ftsWintegral membrane protein involved in stabilizing  
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
pcnBpoly(A) polymerase I 
mrdAtranspeptidase involved in peptidoglycan synthesis 
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(not essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)