Hide | Top

Hide | Top

Hide | Top

Source	Predicted function(s)
NCBI Protein Cluster Prediction	DNA-binding transcriptional regulator PhoP
COMBREX	phoP virulence transcriptional regulatory protein phoP (source organism: Salmonella enterica subsp. enterica serovar Typhimurium; strain specific ID: NCBI_TaxID=90371) [More information on this prediction]

Hide | Top

Hide | Top

Functional Status	Green (experimental evidence, uncurated)
GO terms	BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA CC: GO:0005737 : cytoplasm : IEA MF: GO:0000156 : two-component response regulator activity : IEA BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA BP: GO:0045449 : regulation of transcription : IEA BP: GO:0006350 : transcription : IEA MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD	trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and a response regulator. The former autophosphorylates in a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. The C-terminal effector domain contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunite of RNA polymerase..... (More) PRK10816: DNA-binding transcriptional regulator PhoP; Provisional REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers.... (More) See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	Trans_reg_C Response_reg H See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] CKO_01922 , EcolC_2473 , ECP_1125 , ECs1602 , ECSE_1196 , Ent638_1643 , ESA_02216 , phoP (43) , SARI_01759 , SeAg_B1953 , SeD_A2135 , SeHA_C1348 , SeSA_A1310 , SG1082 , SNSL254_A1332 , SPAB_02283 , Spro_2013 , SSPA1504 , YPA_1890 , YPDSF_1814 , YPK_1715 , YPN_1997 , YPTS_2518

Hide | Top

The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

phoQ sensory histidine kinase in two-component regulato     rluE 23S rRNA U2457 pseudouridine synthase     recR gap repair protein     mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes     xseA exonuclease VII, large subunit     mrdA transpeptidase involved in peptidoglycan synthesis     fabF 3-oxoacyl-[acyl-carrier-protein] synthase II     fabH 3-oxoacyl-[acyl-carrier-protein] synthase III     accA acetyl-CoA carboxylase, carboxytransferase, alpha     polA fused DNA polymerase I 5'->3' polymerase/3'->5' ex     ddlA D-alanine-D-alanine ligase A     recG ATP-dependent DNA helicase     glmU fused N-acetyl glucosamine-1-phosphate uridyltrans     rluF 23S rRNA U2604 pseudouridine synthase     usg predicted semialdehyde dehydrogenase     accC acetyl-CoA carboxylase, biotin carboxylase subunit     clpX ATPase and specificity subunit of ClpX-ClpP ATP-de     mrdB cell wall shape-determining protein     folK 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p     murB UDP-N-acetylenolpyruvoylglucosamine reductase, FAD     priA Primosome factor n' (replication factor Y)     xseB exonuclease VII small subunit     radA DNA repair protein     ftsW integral membrane protein involved in stabilizing     rluB 23S rRNA pseudouridylate synthase     murC UDP-N-acetylmuramate:L-alanine ligase     clpP proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP     mfd transcription-repair coupling factor     recN recombination and repair protein     murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase     fabB 3-oxoacyl-[acyl-carrier-protein] synthase I     ftsI transpeptidase involved in septal peptidoglycan sy     rsuA 16S rRNA U516 pseudouridine synthase     ddlB D-alanine:D-alanine ligase

Hide | Top

Hide | Top