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Gene phoP from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with PhoQ
Member of NCBI Protein Clusters PRK10816(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 945697
UniProtKB accession
RefSeq Protein accession NP_415648.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: phoP
  • locus tag: b1130
  • aliases: ECK1116, JW1116
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 2PKX 2PL1
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10731
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional regulator PhoP
COMBREX phoP virulence transcriptional regulatory protein phoP (source organism: Salmonella enterica subsp. enterica serovar Typhimurium; strain specific ID: NCBI_TaxID=90371) [More information on this prediction]
Source References Functional description
GSDB Under Review transcriptional regulatory protein phoP (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • PRK10816: DNA-binding transcriptional regulator PhoP; Provisional
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_01922 , EcolC_2473 , ECP_1125 , ECs1602 , ECSE_1196 , Ent638_1643 , ESA_02216 , phoP (43) , SARI_01759 , SeAg_B1953 , SeD_A2135 , SeHA_C1348 , SeSA_A1310 , SG1082 , SNSL254_A1332 , SPAB_02283 , Spro_2013 , SSPA1504 , YPA_1890 , YPDSF_1814 , YPK_1715 , YPN_1997 , YPTS_2518
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
phoQsensory histidine kinase in two-component regulato
rluE23S rRNA U2457 pseudouridine synthase 
recRgap repair protein 
xseAexonuclease VII, large subunit 
mrdAtranspeptidase involved in peptidoglycan synthesis 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
ddlAD-alanine-D-alanine ligase A 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
rluF23S rRNA U2604 pseudouridine synthase 
usgpredicted semialdehyde dehydrogenase 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
mrdBcell wall shape-determining protein 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
priAPrimosome factor n' (replication factor Y) 
xseBexonuclease VII small subunit 
radADNA repair protein 
ftsWintegral membrane protein involved in stabilizing  
rluB23S rRNA pseudouridylate synthase 
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
mfdtranscription-repair coupling factor 
recNrecombination and repair protein 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
ddlBD-alanine:D-alanine ligase 
Phenotype Description Expression
Ampicillin sensitivity Knockout confers increased sensitivity to ampicillin Knock out
PMID: 20065048
Cefoxitin sensitivity Knockout confers increased sensitivity to cefoxitin Knock out
PMID: 20065048
Cephradine sensitivity Knockout confers increased sensitivity to cephradine Knock out
PMID: 20065048
Chloramphenicol sensitivity Knockout confers increased sensitivity to chloramphenicol Knock out
PMID: 20065048
Tetracycline sensitivity Knockout confers increased sensitivity to tetracycline Knock out
PMID: 20065048