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Gene frr from Escherichia coli str. K-12 substr. MG1655: ribosome recycling factor
Member of NCBI Protein Clusters PRK00083(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946122
UniProtKB accession
RefSeq Protein accession NP_414714.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: frr
  • locus tag: b0172
  • aliases: ECK0171, JW0167, rrf
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction ribosome recycling factor
Source References Functional description
[PMID: 2684966]
[PMID: 9298646]
[PMID: 8183897]
[PMID: 18723842]
[PMID: 15178758]
Ribosome-recycling factor (source organism: Escherichia coli (strain K12).; strain specific ID: MRE-600)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0006415 : translational termination : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0006412 : translation : IEA
Domain Structure from CDD
  • RRF: Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribo.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03195 , ESA_03170 , frr (63)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
pyrHuridylate kinase
ftsHprotease, ATP-dependent zinc-metallo 
rpsP30S ribosomal subunit protein S16 
pthpeptidyl-tRNA hydrolase 
tufBprotein chain elongation factor EF-Tu (duplicate o 
aspSaspartyl-tRNA synthetase 
yidCmembrane protein insertase 
arnAfused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'- 
tufAprotein chain elongation factor EF-Tu (duplicate o 
rplQ50S ribosomal subunit protein L17 
rplS50S ribosomal subunit protein L19 
fmt10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N 
rpmG50S ribosomal subunit protein L33 
tsfprotein chain elongation factor EF-Ts 
lepAback-translocating Elongation Factor EF4, GTPase 
acpPacyl carrier protein (ACP) 
rluD23S rRNA pseudouridine synthase; specific to U1911 
rplL50S ribosomal subunit protein L7/L12 
rpmA50S ribosomal subunit protein L27 
rncRNase III 
rplI50S ribosomal subunit protein L9 
prfApeptide chain release factor RF-1 
obgEGTPase involved in cell partioning and DNA repair 
rpsR30S ribosomal subunit protein S18 
rluApseudouridine synthase for 23S rRNA (position 746) 
rpmI50S ribosomal subunit protein L35 
ssbsingle-stranded DNA-binding protein 
truCtRNA U65 pseudouridine synthase 
rluC23S rRNA pseudouridine synthase; specific to U955, 
rpsF30S ribosomal subunit protein S6 
mnmAtRNA (5-methylaminomethyl-2-thiouridylate)-methylt 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)