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Gene torR from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with TorS
Member of NCBI Protein Clusters PRK10766(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946182
UniProtKB accession
RefSeq Protein accession NP_415515.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: torR
  • locus tag: b0995
  • aliases: ECK0986, JW0980
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1ZGZ
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12615
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional regulator TorR
Source References Functional description
GSDB Under Review TorCAD operon transcriptional regulatory protein torR (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK10766: DNA-binding transcriptional regulator TorR; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
EcolC_2600 , ECP_0993 , ECs1150 , ECSE_1057 , NT01EI_0301 , SSPA3430 , torR (30)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
domain fusion
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
accAacetyl-CoA carboxylase, carboxytransferase, alpha
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
ddlAD-alanine-D-alanine ligase A
usgpredicted semialdehyde dehydrogenase
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
mrdBcell wall shape-determining protein
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p
xseBexonuclease VII small subunit
murCUDP-N-acetylmuramate:L-alanine ligase
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
radADNA repair protein
recRgap repair protein
rluB23S rRNA pseudouridylate synthase
ftsWintegral membrane protein involved in stabilizing
mfdtranscription-repair coupling factor
rluF23S rRNA U2604 pseudouridine synthase
recNrecombination and repair protein
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
mrdAtranspeptidase involved in peptidoglycan synthesis
fabB3-oxoacyl-[acyl-carrier-protein] synthase I
accCacetyl-CoA carboxylase, biotin carboxylase subunit
ftsItranspeptidase involved in septal peptidoglycan sy
rsuA16S rRNA U516 pseudouridine synthase
fabH3-oxoacyl-[acyl-carrier-protein] synthase III
priAPrimosome factor n' (replication factor Y)
ddlBD-alanine:D-alanine ligase
recGATP-dependent DNA helicase
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
rluE23S rRNA U2457 pseudouridine synthase
xseAexonuclease VII, large subunit
fabF3-oxoacyl-[acyl-carrier-protein] synthase II
yneFpredicted diguanylate cyclase 
ydeHdiguanylate cyclase, required for pgaD induction 
dhaRDNA-binding transcription activator of the dhaKLM  
yfiNpredicted diguanylate cyclase 
dosCdiguanylate cyclase 
yedQpredicted diguanylate cyclase 
yeaJpredicted diguanylate cyclase 
yliFpredicted diguanylate cyclase 
rtcRsigma 54-dependent transcriptional regulator of rt 
ygeVpredicted DNA-binding transcriptional regulator 
hyfRDNA-binding transcriptional activator, formate sen 
yeaIpredicted diguanylate cyclase 
adrAdiguanylate cyclase for cellulose, biofilm, motili 
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re 
yhjKpredicted diguanylate cyclase 
yeaPdiguanylate cyclase 
ydaMdiguanylate cyclase, csgD regulator 
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m 
yegEpredicted diguanylate cyclase, GGDEF domain signal 
ycdTdiguanylate cyclase 
prpRpropionate catabolism operon regulatory protein 
fhlADNA-binding transcriptional activator 
pspFDNA-binding transcriptional activator 
norRAnaerobic nitric oxide reductase DNA-binding trans 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(not essential)
PMID: 20029369
(not essential)