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Gene rstA from Escherichia coli str. K-12 substr. MG1655: multicopy supressor of yjeE, yeaZ or ygjD deletion lethality, predicted response regulator of two-component regulatory system with sensor protein RstB
Member of NCBI Protein Clusters PRK10701(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946199
UniProtKB accession
RefSeq Protein accession NP_416125.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rstA
  • locus tag: b1608
  • aliases: ECK1603, JW1600, urpT
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: G6864
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Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional regulator RstA
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green walR from Bacillus subtilis subsp. subtilis str. 168
(%_identity=39.47; E_val=6e-40; BitScore=159.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green phoP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

to see the rest 51 genes click here
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK10701: DNA-binding transcriptional regulator RstA; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
rstBsensory histidine kinase in two-component regulato
murCUDP-N-acetylmuramate:L-alanine ligase 
rluF23S rRNA U2604 pseudouridine synthase 
xseBexonuclease VII small subunit 
ddlBD-alanine:D-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
usgpredicted semialdehyde dehydrogenase 
ftsItranspeptidase involved in septal peptidoglycan sy 
mrdBcell wall shape-determining protein 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
rluE23S rRNA U2457 pseudouridine synthase 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
rsuA16S rRNA U516 pseudouridine synthase 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
radADNA repair protein 
mrdAtranspeptidase involved in peptidoglycan synthesis 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
xseAexonuclease VII, large subunit 
recGATP-dependent DNA helicase 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
ddlAD-alanine-D-alanine ligase A 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
recNrecombination and repair protein 
mfdtranscription-repair coupling factor 
rluB23S rRNA pseudouridylate synthase 
recRgap repair protein 
priAPrimosome factor n' (replication factor Y) 
ftsWintegral membrane protein involved in stabilizing