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Gene ftsW from Escherichia coli str. K-12 substr. MG1655: integral membrane protein involved in stabilizing FstZ ring during cell division
Member of NCBI Protein Clusters PRK10774(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946322
UniProtKB accession
RefSeq Protein accession NP_414631.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ftsW
  • locus tag: b0089
  • aliases: ECK0090, JW0087
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10344
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction cell division protein FtsW
Source References Functional description
GSDB
[PMID: 9218774]
[PMID: 15919996]
Cell division protein ftsW (source organism: Escherichia coli (strain K12).; strain specific ID: K12 / W3110 / ATCC 27325 / DSM 5911)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000910 : cytokinesis : IMP
  • BP: GO:0007049 : cell cycle : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • BP: GO:0008360 : regulation of cell shape : IMP
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • BP: GO:0051301 : cell division : IMP
  • CC: GO:0016020 : membrane : IEA
  • CC: GO:0032155 : cell division site part : IDA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • MF: GO:0005515 : protein binding : IDA
  • BP: GO:0051301 : cell division : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
Domain Structure from CDD
  • FTSW_RODA_SPOVE: Cell cycle protein. cell wall shape-determining protein; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03286 , EcolC_3568 , ECP_0091 , ECs0093 , ECSE_0091 , Ent638_0635 , ESA_03249 , ftsW (41) , SARI_02874 , SPAB_00161 , SSPA0125
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 gene neighbourhoods
phylogenetic profile
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
 
 
murGN-acetylglucosaminyl transferase
 
 
priAPrimosome factor n' (replication factor Y) 
 
prfBpeptide chain release factor RF-2 
 
baeRDNA-binding response regulator in two-component re 
 
murCUDP-N-acetylmuramate:L-alanine ligase 
 
rluF23S rRNA U2604 pseudouridine synthase 
 
ompRDNA-binding response regulator in two-component re 
 
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-dia 
 
ddlBD-alanine:D-alanine ligase 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
 
creBDNA-binding response regulator in two-component re 
 
basRDNA-binding response regulator in two-component re 
 
yaeJconserved protein 
 
ftsItranspeptidase involved in septal peptidoglycan sy 
 
phoBDNA-binding response regulator in two-component re 
 
qseBquorum sensing DNA-binding response regulator in t 
 
ygeRnovel lipoprotein, function unknown 
 
torRDNA-binding response regulator in two-component re 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
 
nlpDnovel lipoprotein, function unknown 
 
rluE23S rRNA U2457 pseudouridine synthase 
 
pnppolynucleotide phosphorylase/polyadenylase 
 
yajCSecYEG protein translocase auxillary subunit 
 
cusRDNA-binding response regulator in two-component re 
 
rsuA16S rRNA U516 pseudouridine synthase 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
 
radADNA repair protein 
 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de 
 
arcADNA-binding response regulator in two-component re 
 
yebApredicted peptidase 
 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
 
yggWpredicted oxidoreductase, HemN family 
 
mrdAtranspeptidase involved in peptidoglycan synthesis 
 
rpsA30S ribosomal subunit protein S1 
 
phoPDNA-binding response regulator in two-component re 
 
secGpreprotein translocase membrane subunit 
 
recGATP-dependent DNA helicase 
 
ddlAD-alanine-D-alanine ligase A 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes 
 
kdpEDNA-binding response regulator in two-component re 
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
 
cpxRDNA-binding response regulator in two-component re 
 
yedWpredicted DNA-binding response regulator in two-co 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
 
rimM16S rRNA processing protein 
 
mfdtranscription-repair coupling factor 
 
rluB23S rRNA pseudouridylate synthase 
 
pcnBpoly(A) polymerase I 
 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)