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Functional Status	Green (experimental evidence, uncurated)
GO terms	BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA CC: GO:0005622 : intracellular : IEA BP: GO:0045449 : regulation of transcription : IEA BP: GO:0006350 : transcription : IEA MF: GO:0005515 : protein binding : IPI MF: GO:0003677 : DNA binding : IEA BP: GO:0007600 : sensory perception : IEA CC: GO:0005737 : cytoplasm : IEA BP: GO:0006350 : transcription : ISS MF: GO:0000156 : two-component response regulator activity : IEA MF: GO:0016563 : transcription activator activity : ISS BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
Domain Structure from CDD	trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and a response regulator. The former autophosphorylates in a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. The C-terminal effector domain contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunite of RNA polymerase..... (More) REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers.... (More) PRK11517: transcriptional regulatory protein YedW; Provisional See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	Trans_reg_C Response_reg H See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] EcE24377A_2200 , ECH74115_2748 , EcHS_A2070 , EcolC_1676 , ECP_1902 , ECs2707 , ECSE_2198 , EcSMS35_1216 , SbBS512_E0914 , yedW (19)

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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

yedV predicted sensory kinase in two-component regulato       fabF 3-oxoacyl-[acyl-carrier-protein] synthase II       murB UDP-N-acetylenolpyruvoylglucosamine reductase, FAD       accA acetyl-CoA carboxylase, carboxytransferase, alpha       polA fused DNA polymerase I 5'->3' polymerase/3'->5' ex       ddlA D-alanine-D-alanine ligase A       usg predicted semialdehyde dehydrogenase       clpX ATPase and specificity subunit of ClpX-ClpP ATP-de       folK 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p       xseB exonuclease VII small subunit       murC UDP-N-acetylmuramate:L-alanine ligase       clpP proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP       radA DNA repair protein       rluB 23S rRNA pseudouridylate synthase       recR gap repair protein       mfd transcription-repair coupling factor       mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes       recN recombination and repair protein       murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase       fabB 3-oxoacyl-[acyl-carrier-protein] synthase I       mrdA transpeptidase involved in peptidoglycan synthesis       ftsI transpeptidase involved in septal peptidoglycan sy       rsuA 16S rRNA U516 pseudouridine synthase       priA Primosome factor n' (replication factor Y)       ddlB D-alanine:D-alanine ligase       mrdB cell wall shape-determining protein       fabH 3-oxoacyl-[acyl-carrier-protein] synthase III       ftsW integral membrane protein involved in stabilizing       rluE 23S rRNA U2457 pseudouridine synthase       recG ATP-dependent DNA helicase       glmU fused N-acetyl glucosamine-1-phosphate uridyltrans       rluF 23S rRNA U2604 pseudouridine synthase       accC acetyl-CoA carboxylase, biotin carboxylase subunit       xseA exonuclease VII, large subunit       kdpD fused sensory histidine kinase in two-component re       torS hybrid sensory histidine kinase in two-component r       barA hybrid sensory histidine kinase, in two-component       phoR sensory histidine kinase in two-component regulato       cusS sensory histidine kinase in two-component regulato       zraS sensory histidine kinase in two-component regulato       glrK Sensor protein kinase regulating glmY sRNA in two-       cpxA sensory histidine kinase in two-component regulato       glnL sensory histidine kinase in two-component regulato       atoS sensory histidine kinase in two-component regulato       basS sensory histidine kinase in two-component regulato       rstB sensory histidine kinase in two-component regulato       evgS hybrid sensory histidine kinase in two-component r       arcB aerobic respiration control sensor histidine prote       creC sensory histidine kinase in two-component regulato       rcsC hybrid sensory kinase in two-component regulatory       baeS sensory histidine kinase in two-component regulato