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Gene yedW from Escherichia coli str. K-12 substr. MG1655: predicted DNA-binding response regulator in two-component system with YedV
Member of NCBI Protein Clusters PRK11517(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 946486
UniProtKB accession
RefSeq Protein accession NP_416478.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: yedW
  • locus tag: b1969
  • aliases: ECK1965, JW5322
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: G7057
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Source Predicted function(s)
NCBI Protein Cluster Prediction transcriptional regulatory protein YedW
Source References Functional description
GSDB Under Review probable transcriptional regulatory protein yedW (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005622 : intracellular : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0007600 : sensory perception : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0006350 : transcription : ISS
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • MF: GO:0016563 : transcription activator activity : ISS
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK11517: transcriptional regulatory protein YedW; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
EcE24377A_2200 , ECH74115_2748 , EcHS_A2070 , EcolC_1676 , ECP_1902 , ECs2707 , ECSE_2198 , EcSMS35_1216 , SbBS512_E0914 , yedW (19)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
domain fusion
yedVpredicted sensory kinase in two-component regulato
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
ddlAD-alanine-D-alanine ligase A 
usgpredicted semialdehyde dehydrogenase 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
xseBexonuclease VII small subunit 
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
radADNA repair protein 
rluB23S rRNA pseudouridylate synthase 
recRgap repair protein 
mfdtranscription-repair coupling factor 
recNrecombination and repair protein 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
mrdAtranspeptidase involved in peptidoglycan synthesis 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
priAPrimosome factor n' (replication factor Y) 
ddlBD-alanine:D-alanine ligase 
mrdBcell wall shape-determining protein 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
ftsWintegral membrane protein involved in stabilizing  
rluE23S rRNA U2457 pseudouridine synthase 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
rluF23S rRNA U2604 pseudouridine synthase 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
xseAexonuclease VII, large subunit 
kdpDfused sensory histidine kinase in two-component re  
torShybrid sensory histidine kinase in two-component r  
barAhybrid sensory histidine kinase, in two-component   
phoRsensory histidine kinase in two-component regulato  
cusSsensory histidine kinase in two-component regulato  
zraSsensory histidine kinase in two-component regulato  
glrKSensor protein kinase regulating glmY sRNA in two-  
cpxAsensory histidine kinase in two-component regulato  
glnLsensory histidine kinase in two-component regulato  
atoSsensory histidine kinase in two-component regulato  
basSsensory histidine kinase in two-component regulato  
rstBsensory histidine kinase in two-component regulato  
evgShybrid sensory histidine kinase in two-component r  
arcBaerobic respiration control sensor histidine prote  
creCsensory histidine kinase in two-component regulato  
rcsChybrid sensory kinase in two-component regulatory   
baeSsensory histidine kinase in two-component regulato