Gene yphF from Escherichia coli str. K-12 substr. MG1655: predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily
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Member of NCBI Protein Clusters
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CLSK880430(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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947020
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UniProtKB accession
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RefSeq Protein accession
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NP_417043.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: yphF
- locus tag: b2548
- aliases: ECK2545, JW2532
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Organism
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Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
G7342
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Source
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Predicted function(s)
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NCBI Protein Cluster Prediction
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putative sugar transporter subunit: periplasmic-binding component of ABC superfamily
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| Source |
References |
Functional description |
| GSDB |
Under Review
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ABC transporter periplasmic-binding protein yphF (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333) |
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Functional Status
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Green (experimental evidence, uncurated)
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GO terms
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BP:
GO:0006810 : transport : IEA
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CC:
GO:0042597 : periplasmic space : IEA
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Domain Structure from CDD
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- RbsB: ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]
- PBP1_ABC_sugar_binding_like: Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily. Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily. The members of this family function as the primary receptors for chemotaxis and transport of many sugar based solutes in bacteria and archaea. The sugar binding domain is also homologous to the ligand-binding domain of eukaryotic receptors such as glutamate receptor (GluR) and DNA-binding transcriptional repressors such as LacI and GalR. Moreover, this periplasmic binding domain, also known as Venus flytrap domain, undergoes transition from an open to a closed conformational state upon the binding of ligands such as lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. This family also includes the periplasmic binding domain of autoinducer-2 (AI-2) receptors such as LsrB and LuxP which are highly homologous to periplasmic pentose/hexose sugar-binding proteins..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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Based on the function of this gene, COMBREX predictions were made to the following related genes
(mouse over gene symbol for details)
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[Download  ]
EcE24377A_2833
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ECH74115_3781
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EcHS_A2700
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EcolC_1129
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ECP_2549
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ECs3414
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ECSE_2835
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EcSMS35_2701
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yphF
(16)
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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| | yphE | fused predicted sugar transporter subunits of ABC | | | | rbsC | D-ribose transporter subunit | | | | lsrC | Autoinducer 2 import system permease protein | | | | araH | fused L-arabinose transporter subunits of ABC supe | | | | lsrD | autoinducer 2 import system permease protein | | | | xylH | D-xylose ABC transporter permease subunit | | | | mglC | methyl-galactoside transporter subunit | | | | alsC | D-allose transporter subunit | | | | ytfT | predicted sugar transporter subunit: membrane comp | | | | yjfF | predicted sugar transporter subunit: membrane comp | | | | yphD | predicted sugar transporter subunit: membrane comp | | |
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