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Gene coaD from Escherichia coli str. K-12 substr. MG1655: pantetheine-phosphate adenylyltransferase
Member of NCBI Protein Clusters PRK00168(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947386
UniProtKB accession
RefSeq Protein accession NP_418091.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: coaD
  • locus tag: b3634
  • aliases: ECK3624, JW3609, kdtB, yicA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction phosphopantetheine adenylyltransferase
Source References Functional description
[PMID: 10480925]
[PMID: 1577693]
[PMID: 10205156]
[PMID: 11812124]
Phosphopantetheine adenylyltransferase (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • BP: GO:0015937 : coenzyme A biosynthetic process : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0004595 : pantetheine-phosphate adenylyltransferase activity : IEA
  • MF: GO:0016779 : nucleotidyltransferase activity : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004595 : pantetheine-phosphate adenylyltransferase activity : IDA
  • BP: GO:0015937 : coenzyme A biosynthetic process : IDA
Domain Structure from CDD
  • NadD: Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]
  • PPAT_a: Phosphopantetheine adenylyltransferase. Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in bacteria.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
coaD (49)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
gene neighbourhoods
recGATP-dependent DNA helicase
waaA3-deoxy-D-manno-octulosonic-acid transferase (KDO  
rluF23S rRNA U2604 pseudouridine synthase
rluE23S rRNA U2457 pseudouridine synthase
rimM16S rRNA processing protein
mtgAbiosynthetic peptidoglycan transglycosylase
murIglutamate racemase
rluB23S rRNA pseudouridylate synthase
mrcBfused glycosyl transferase and transpeptidase
rsuA16S rRNA U516 pseudouridine synthase
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PTPATi

pantetheine-phosphate adenylyltransferase
atp[c] + h[c] + pan4p[c] -> dpcoa[c] + ppi[c]
Cofactor and Prosthetic Group Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)