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Gene murA from Escherichia coli str. K-12 substr. MG1655: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Member of NCBI Protein Clusters PRK09369(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947703
UniProtKB accession
RefSeq Protein accession NP_417656.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: murA
  • locus tag: b3189
  • aliases: ECK3178, JW3156, mrbA, murZ
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction UDP-N-acetylglucosamine 1-carboxyvinyltransferase
COMBREX murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase (source organism: Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56).; strain specific ID: ) [More information on this prediction]
Source References Functional description
[PMID: 1512209]
[PMID: 8994972]
[PMID: 9485407]
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (source organism: Escherichia coli (strain K12).; strain specific ID: K12 / AB1157)
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • MF: GO:0008760 : UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity : IDA
  • MF: GO:0008760 : UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity : IEA
  • MF: GO:0016765 : transferase activity, transferring alkyl or aryl (other than methyl) groups : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • BP: GO:0019277 : UDP-N-acetylgalactosamine biosynthetic process : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0051301 : cell division : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
Domain Structure from CDD
  • UdpNAET: UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynth.... (More)
  • murA: UDP-N-acetylglucosamine 1-carboxyvinyltransferase.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_04592 , EcolC_0511 , ECP_3276 , ECs4068 , ECSE_3473 , Ent638_3625 , ESA_03582 , murA (53) , NT01EI_0586 , SARI_04318 , SG0211 , SPAB_04124 , Spro_4354 , SSPA2962 , Tola_2926 , VC2514 , VCD_001844 , YPA_3734 , YPDSF_0328 , YPK_0518 , YPN_3451 , YPTS_3699
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
yrbApredicted DNA-binding transcriptional regulator, B
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
ddlBD-alanine:D-alanine ligase 
rpsA30S ribosomal subunit protein S1 
kdpEDNA-binding response regulator in two-component re 
rluE23S rRNA U2457 pseudouridine synthase 
mrdAtranspeptidase involved in peptidoglycan synthesis 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de 
murGN-acetylglucosaminyl transferase 
cusRDNA-binding response regulator in two-component re 
phoBDNA-binding response regulator in two-component re 
ompRDNA-binding response regulator in two-component re 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
qseBquorum sensing DNA-binding response regulator in t 
pnppolynucleotide phosphorylase/polyadenylase 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
torRDNA-binding response regulator in two-component re 
rluF23S rRNA U2604 pseudouridine synthase 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
ddlAD-alanine-D-alanine ligase A 
yedWpredicted DNA-binding response regulator in two-co 
nlpDnovel lipoprotein, function unknown 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
priAPrimosome factor n' (replication factor Y) 
yggWpredicted oxidoreductase, HemN family 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
pcnBpoly(A) polymerase I 
secGpreprotein translocase membrane subunit 
yaeJconserved protein 
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
rimM16S rRNA processing protein 
phoPDNA-binding response regulator in two-component re 
arcADNA-binding response regulator in two-component re 
yajCSecYEG protein translocase auxillary subunit 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
mrdBcell wall shape-determining protein 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
creBDNA-binding response regulator in two-component re 
rluB23S rRNA pseudouridylate synthase 
ygeRnovel lipoprotein, function unknown 
basRDNA-binding response regulator in two-component re 
prfBpeptide chain release factor RF-2 
cpxRDNA-binding response regulator in two-component re 
radADNA repair protein 
baeRDNA-binding response regulator in two-component re 
ftsWintegral membrane protein involved in stabilizing  
mfdtranscription-repair coupling factor 
yebApredicted peptidase 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: UAGCVT

UDP-N-acetylglucosamine 1-carboxyvinyltransferase
pep[c] + uacgam[c] -> pi[c] + uaccg[c]
Cell Envelope Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(not essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)