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Gene ompR from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with EnvZ
Member of NCBI Protein Clusters PRK09468(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 947913
UniProtKB accession
RefSeq Protein accession NP_417864.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ompR
  • locus tag: b3405
  • aliases: ECK3392, JW3368, kmt, ompB
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1ODD 1OPC 2JPB
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10672
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Source Predicted function(s)
NCBI Protein Cluster Prediction osmolarity response regulator
Source References Functional description
GSDB Under Review transcriptional regulatory protein ompR (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • ompR: osmolarity response regulator; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
NT01EI_3645 , ompR (81) , VCD_001653
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
domain fusion
envZsensory histidine kinase in two-component regulato
mrdBcell wall shape-determining protein 
usgpredicted semialdehyde dehydrogenase 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
ftsWintegral membrane protein involved in stabilizing  
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
xseBexonuclease VII small subunit 
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
radADNA repair protein 
rluB23S rRNA pseudouridylate synthase 
recRgap repair protein 
mfdtranscription-repair coupling factor 
rluF23S rRNA U2604 pseudouridine synthase 
recNrecombination and repair protein 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
recGATP-dependent DNA helicase 
mrdAtranspeptidase involved in peptidoglycan synthesis 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
priAPrimosome factor n' (replication factor Y) 
ddlBD-alanine:D-alanine ligase 
rluE23S rRNA U2457 pseudouridine synthase 
xseAexonuclease VII, large subunit 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
ddlAD-alanine-D-alanine ligase A 
yedQpredicted diguanylate cyclase  
cpxAsensory histidine kinase in two-component regulato  
yedVpredicted sensory kinase in two-component regulato  
tyrRDNA-binding transcriptional dual regulator, tyrosi  
glnLsensory histidine kinase in two-component regulato  
ydeHdiguanylate cyclase, required for pgaD induction  
dhaRDNA-binding transcription activator of the dhaKLM   
zraSsensory histidine kinase in two-component regulato  
yfiNpredicted diguanylate cyclase  
ypdApredicted sensory kinase in two-component system w  
yeaJpredicted diguanylate cyclase  
yliFpredicted diguanylate cyclase  
rtcRsigma 54-dependent transcriptional regulator of rt  
ygeVpredicted DNA-binding transcriptional regulator  
hyfRDNA-binding transcriptional activator, formate sen  
basSsensory histidine kinase in two-component regulato  
yeaIpredicted diguanylate cyclase  
yehUpredicted sensory kinase in two-component system w  
arcBaerobic respiration control sensor histidine prote  
adrAdiguanylate cyclase for cellulose, biofilm, motili  
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re  
yhjKpredicted diguanylate cyclase  
evgShybrid sensory histidine kinase in two-component r  
creCsensory histidine kinase in two-component regulato  
rcsChybrid sensory kinase in two-component regulatory   
baeSsensory histidine kinase in two-component regulato  
rstBsensory histidine kinase in two-component regulato  
yeaPdiguanylate cyclase  
ydaMdiguanylate cyclase, csgD regulator  
glrKSensor protein kinase regulating glmY sRNA in two-  
ycdTdiguanylate cyclase  
kdpDfused sensory histidine kinase in two-component re  
torShybrid sensory histidine kinase in two-component r  
prpRpropionate catabolism operon regulatory protein  
fhlADNA-binding transcriptional activator  
pspFDNA-binding transcriptional activator  
barAhybrid sensory histidine kinase, in two-component   
norRAnaerobic nitric oxide reductase DNA-binding trans  
atoSsensory histidine kinase in two-component regulato  
yneFpredicted diguanylate cyclase  
cusSsensory histidine kinase in two-component regulato  
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m  
yegEpredicted diguanylate cyclase, GGDEF domain signal  
phoRsensory histidine kinase in two-component regulato  
dosCdiguanylate cyclase