Gene rsmD from Escherichia coli str. K-12 substr. MG1655: 16S rRNA m(2)G966 methyltransferase, SAM-dependent
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Member of NCBI Protein Clusters
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PRK10909(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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947977
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UniProtKB accession
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RefSeq Protein accession
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NP_417922.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: rsmD
- locus tag: b3465
- aliases: ECK3449, JW3430, yhhF
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Organism
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Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
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Other Cross References:
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S Structure(s) available in PDB:
2FPO
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
EG10343
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Source
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Predicted function(s)
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NCBI Protein Cluster Prediction
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16S rRNA m(2)G966-methyltransferase
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Functional description |
| GSDB |
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Ribosomal RNA small subunit methyltransferase D (source organism: Escherichia coli (strain K12).; strain specific ID: ) |
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Functional Status
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Green (experimental evidence, uncurated)
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EC number
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2.1.1.52 (See reaction via BRENDA)) (Source: BRENDA)
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GO terms
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BP:
GO:0006364 : rRNA processing : IEA
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MF:
GO:0008990 : rRNA (guanine-N2-)-methyltransferase activity : IDA
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MF:
GO:0008168 : methyltransferase activity : IEA
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BP:
GO:0070475 : rRNA base methylation : IMP
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MF:
GO:0003676 : nucleic acid binding : IEA
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MF:
GO:0005515 : protein binding : IPI
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MF:
GO:0008990 : rRNA (guanine-N2-)-methyltransferase activity : IEA
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MF:
GO:0016740 : transferase activity : IEA
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BP:
GO:0032259 : methylation : IEA
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Domain Structure from CDD
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- AdoMet_MTases: S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.)..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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Based on the function of this gene, COMBREX predictions were made to the following related genes
(mouse over gene symbol for details)
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[Download  ]
rsmD
(49)
,
yhhF
(2)
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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| | 
 | | murB | UDP-N-acetylenolpyruvoylglucosamine reductase, FAD | | | clpX | ATPase and specificity subunit of ClpX-ClpP ATP-de | | | rpsA | 30S ribosomal subunit protein S1 | | | murC | UDP-N-acetylmuramate:L-alanine ligase | | | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes | | | clpP | proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP | | | rluB | 23S rRNA pseudouridylate synthase | | | mrdB | cell wall shape-determining protein | | | mrdA | transpeptidase involved in peptidoglycan synthesis | | | mfd | transcription-repair coupling factor | | | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | | | ftsW | integral membrane protein involved in stabilizing | | | ftsI | transpeptidase involved in septal peptidoglycan sy | | | rsuA | 16S rRNA U516 pseudouridine synthase | | | priA | Primosome factor n' (replication factor Y) | | | rluF | 23S rRNA U2604 pseudouridine synthase | | | rluE | 23S rRNA U2457 pseudouridine synthase | |
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