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Gene recG from Escherichia coli str. K-12 substr. MG1655: ATP-dependent DNA helicase
Member of NCBI Protein Clusters PRK10917(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948162
UniProtKB accession
RefSeq Protein accession NP_418109.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: recG
  • locus tag: b3652
  • aliases: ECK3642, JW3627, radC, spoV
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10829
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction ATP-dependent DNA helicase RecG
Source References Functional description
GSDB Under Review ATP-dependent DNA helicase RecG (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
EC number 3.6.1.- (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0008026 : ATP-dependent helicase activity : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • BP: GO:0006310 : DNA recombination : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0004003 : ATP-dependent DNA helicase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • MF: GO:0004386 : helicase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • DEXDc: DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domai.... (More)
  • RecG_wedge_OBF: RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherich.... (More)
  • PRK10917: ATP-dependent DNA helicase RecG; Provisional
  • HELICc: Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_05109 , EcolC_0059 , ECP_3750 , ECs4527 , ECSE_3934 , Ent638_0087 , ESA_04074 , recG (50) , SARI_03895 , SPAB_04645 , Spro_4871 , SSPA3359 , YPA_3506 , YPDSF_3869 , YPK_4180 , YPN_3814 , YPTS_0034
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
domain fusion
coaDpantetheine-phosphate adenylyltransferase
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
macAmacrolide transporter subunit, membrane fusion pro
gyrBDNA gyrase, subunit B
ddlAD-alanine-D-alanine ligase A
rsmG16S rRNA m(7)G527 methyltransferase, SAM-dependent
kdpEDNA-binding response regulator in two-component re
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
xseBexonuclease VII small subunit
mrdAtranspeptidase involved in peptidoglycan synthesis
murCUDP-N-acetylmuramate:L-alanine ligase
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
rluB23S rRNA pseudouridylate synthase
ygeRnovel lipoprotein, function unknown
phoBDNA-binding response regulator in two-component re
ompRDNA-binding response regulator in two-component re
basRDNA-binding response regulator in two-component re
mdtEmultidrug resistance efflux transporter
phoPDNA-binding response regulator in two-component re
ybhGpredicted membrane fusion protein (MFP) component
alralanine racemase 1, PLP-binding, biosynthetic
mfdtranscription-repair coupling factor
yebApredicted peptidase
rluF23S rRNA U2604 pseudouridine synthase
recNrecombination and repair protein
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
mrdBcell wall shape-determining protein
cusBcopper/silver efflux system, membrane fusion prote
mdtAmultidrug efflux system, subunit A
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
hslOheat shock protein Hsp33
creBDNA-binding response regulator in two-component re
ftsItranspeptidase involved in septal peptidoglycan sy
rsuA16S rRNA U516 pseudouridine synthase
priAPrimosome factor n' (replication factor Y)
ddlBD-alanine:D-alanine ligase
acrAmultidrug efflux system
baeRDNA-binding response regulator in two-component re
ftsWintegral membrane protein involved in stabilizing
arcADNA-binding response regulator in two-component re
cpxRDNA-binding response regulator in two-component re
torRDNA-binding response regulator in two-component re
yhiIpredicted membrane fusion protein (MFP) of efflux
rluE23S rRNA U2457 pseudouridine synthase
dadXalanine racemase 2, PLP-binding
cusRDNA-binding response regulator in two-component re
yedWpredicted DNA-binding response regulator in two-co
nlpDnovel lipoprotein, function unknown
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
rimM16S rRNA processing protein
qseBquorum sensing DNA-binding response regulator in t
uvrBexcinulease of nucleotide excision repair, DNA dam 
Phenotype Description Expression
Ciprofloxacin sensitivity Knockout confers increased sensitivity to ciprofloxacin Knock out
PMID: 20065048
Enoxacin sensitivity Knockout confers increased sensitivity to enoxacin Knock out
PMID: 20065048
Metronidazole sensitivity Knockout confers increased sensitivity to metronidazole Knock out
PMID: 20065048
Nitrofurantoin sensitivity Knockout confers increased sensitivity to nitrofurantoin Knock out
PMID: 20065048
Sulfamethoxazole sensitivity Knockout confers increased sensitivity to sulfamethoxazole Knock out
PMID: 20065048