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Gene recG from Escherichia coli str. K-12 substr. MG1655: ATP-dependent DNA helicase
Member of NCBI Protein Clusters PRK10917(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948162
UniProtKB accession
RefSeq Protein accession NP_418109.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: recG
  • locus tag: b3652
  • aliases: ECK3642, JW3627, radC, spoV
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10829
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ATP-dependent DNA helicase RecG
Source References Functional description
GSDB Under Review ATP-dependent DNA helicase RecG (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
EC number 3.6.1.- (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0008026 : ATP-dependent helicase activity : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • BP: GO:0006310 : DNA recombination : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0004003 : ATP-dependent DNA helicase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0006974 : response to DNA damage stimulus : IEA
  • MF: GO:0004386 : helicase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • DEXDc: DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domai.... (More)
  • RecG_wedge_OBF: RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherich.... (More)
  • PRK10917: ATP-dependent DNA helicase RecG; Provisional
  • HELICc: Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_05109 , EcolC_0059 , ECP_3750 , ECs4527 , ECSE_3934 , Ent638_0087 , ESA_04074 , recG (50) , SARI_03895 , SPAB_04645 , Spro_4871 , SSPA3359 , YPA_3506 , YPDSF_3869 , YPK_4180 , YPN_3814 , YPTS_0034
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
domain fusion
coaDpantetheine-phosphate adenylyltransferase
 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
 
macAmacrolide transporter subunit, membrane fusion pro
 
 
gyrBDNA gyrase, subunit B
 
 
ddlAD-alanine-D-alanine ligase A
 
 
rsmG16S rRNA m(7)G527 methyltransferase, SAM-dependent
 
 
kdpEDNA-binding response regulator in two-component re
 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
 
xseBexonuclease VII small subunit
 
 
mrdAtranspeptidase involved in peptidoglycan synthesis
 
 
murCUDP-N-acetylmuramate:L-alanine ligase
 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
 
rluB23S rRNA pseudouridylate synthase
 
 
ygeRnovel lipoprotein, function unknown
 
 
phoBDNA-binding response regulator in two-component re
 
 
ompRDNA-binding response regulator in two-component re
 
 
basRDNA-binding response regulator in two-component re
 
 
mdtEmultidrug resistance efflux transporter
 
 
phoPDNA-binding response regulator in two-component re
 
 
ybhGpredicted membrane fusion protein (MFP) component
 
 
alralanine racemase 1, PLP-binding, biosynthetic
 
 
mfdtranscription-repair coupling factor
 
 
yebApredicted peptidase
 
 
rluF23S rRNA U2604 pseudouridine synthase
 
 
recNrecombination and repair protein
 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
 
mrdBcell wall shape-determining protein
 
 
cusBcopper/silver efflux system, membrane fusion prote
 
 
mdtAmultidrug efflux system, subunit A
 
 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
 
 
hslOheat shock protein Hsp33
 
 
creBDNA-binding response regulator in two-component re
 
 
ftsItranspeptidase involved in septal peptidoglycan sy
 
 
rsuA16S rRNA U516 pseudouridine synthase
 
 
priAPrimosome factor n' (replication factor Y)
 
 
ddlBD-alanine:D-alanine ligase
 
 
acrAmultidrug efflux system
 
 
baeRDNA-binding response regulator in two-component re
 
 
ftsWintegral membrane protein involved in stabilizing
 
 
arcADNA-binding response regulator in two-component re
 
 
cpxRDNA-binding response regulator in two-component re
 
 
torRDNA-binding response regulator in two-component re
 
 
yhiIpredicted membrane fusion protein (MFP) of efflux
 
 
rluE23S rRNA U2457 pseudouridine synthase
 
 
dadXalanine racemase 2, PLP-binding
 
 
cusRDNA-binding response regulator in two-component re
 
 
yedWpredicted DNA-binding response regulator in two-co
 
 
nlpDnovel lipoprotein, function unknown
 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
 
rimM16S rRNA processing protein
 
 
qseBquorum sensing DNA-binding response regulator in t
 
 
uvrBexcinulease of nucleotide excision repair, DNA dam 
 
Phenotype Description Expression
Class
Reference(s)
Ciprofloxacin sensitivity Knockout confers increased sensitivity to ciprofloxacin Knock out
PMID: 20065048
Enoxacin sensitivity Knockout confers increased sensitivity to enoxacin Knock out
PMID: 20065048
Metronidazole sensitivity Knockout confers increased sensitivity to metronidazole Knock out
PMID: 20065048
Nitrofurantoin sensitivity Knockout confers increased sensitivity to nitrofurantoin Knock out
PMID: 20065048
Sulfamethoxazole sensitivity Knockout confers increased sensitivity to sulfamethoxazole Knock out
PMID: 20065048