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Gene hemN from Escherichia coli str. K-12 substr. MG1655: coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent
Member of NCBI Protein Clusters PRK09249(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948362
UniProtKB accession
RefSeq Protein accession NP_418303.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: hemN
  • locus tag: b3867
  • aliases: ECK3860, JW3838, yihJ
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1OLT
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11836
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Source Predicted function(s)
NCBI Protein Cluster Prediction coproporphyrinogen III oxidase
Source References Functional description
GSDB
[PMID: 12114526]
[PMID: 15967800]
[PMID: 14633981]
Oxygen-independent coproporphyrinogen-III oxidase (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0051539 : 4 iron, 4 sulfur cluster binding : IDA
  • MF: GO:0051989 : coproporphyrinogen dehydrogenase activity : IDA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
  • MF: GO:0004109 : coproporphyrinogen oxidase activity : IEA
  • MF: GO:0005506 : iron ion binding : IEA
  • MF: GO:0051989 : coproporphyrinogen dehydrogenase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0019353 : protoporphyrinogen IX biosynthetic process from glutamate : IGI
  • BP: GO:0006779 : porphyrin biosynthetic process : IEA
  • MF: GO:0051539 : 4 iron, 4 sulfur cluster binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • PRK09249: coproporphyrinogen III oxidase; Provisional
  • HemN_C: HemN C-terminal region. Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This e.... (More)
  • Radical_SAM: Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03145 , EcolC_4149 , ECP_4077 , ECs4789 , ECSE_4150 , Ent638_4099 , ESA_04045 , hemN (42) , SARI_03656 , SPAB_04966 , Spro_4884 , SSPA3575
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
secGpreprotein translocase membrane subunit
 
murCUDP-N-acetylmuramate:L-alanine ligase
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
radADNA repair protein
 
rluB23S rRNA pseudouridylate synthase
 
mfdtranscription-repair coupling factor
 
rluF23S rRNA U2604 pseudouridine synthase
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
ftsItranspeptidase involved in septal peptidoglycan sy
 
rsuA16S rRNA U516 pseudouridine synthase
 
priAPrimosome factor n' (replication factor Y)
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
mrdBcell wall shape-determining protein
 
mrdAtranspeptidase involved in peptidoglycan synthesis
 
rluE23S rRNA U2457 pseudouridine synthase
 
ftsWintegral membrane protein involved in stabilizing
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de