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Gene cpxR from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with CpxA
Member of NCBI Protein Clusters PRK10955(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948404
UniProtKB accession
RefSeq Protein accession NP_418348.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: cpxR
  • locus tag: b3912
  • aliases: ECK3905, JW3883, yiiA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10020
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding transcriptional regulator CpxR
Source References Functional description
GSDB Under Review Transcriptional regulatory protein CpxR (source organism: Escherichia coli (strain K12).; strain specific ID: L547)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • BP: GO:0006350 : transcription : IEP
  • MF: GO:0016563 : transcription activator activity : IDA
  • BP: GO:0043193 : positive regulation of gene-specific transcription : ISS
  • MF: GO:0016564 : transcription repressor activity : IDA
  • MF: GO:0016566 : specific transcriptional repressor activity : IDA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • MF: GO:0016564 : transcription repressor activity : IEP
  • MF: GO:0016563 : transcription activator activity : ISS
  • BP: GO:0043193 : positive regulation of gene-specific transcription : IDA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • MF: GO:0003700 : transcription factor activity : ISS
  • BP: GO:0032582 : negative regulation of gene-specific transcription : IDA
  • MF: GO:0005515 : protein binding : IPI
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0016563 : transcription activator activity : IEP
  • MF: GO:0016566 : specific transcriptional repressor activity : ISS
  • BP: GO:0006350 : transcription : IDA
  • BP: GO:0045449 : regulation of transcription : IEA
  • MF: GO:0003700 : transcription factor activity : IDA
  • BP: GO:0032582 : negative regulation of gene-specific transcription : ISS
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK10955: DNA-binding transcriptional regulator CpxR; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03088 , cpxR (50) , cpxR1 , cpxR2 (2) , EcolC_4105 , ECP_4122 , ECs4838 , ECSE_4201 , Ent638_4060 , ESA_04123 , NT01EI_3811 , SARI_03585 , SG2180 , SPAB_05031 , Spro_4810 , SSPA3630 , YPA_3469 , YPDSF_3832 , YPK_4132 , YPN_3777 , YPTS_0071
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
gene neighbourhoods
domain fusion
rsuA16S rRNA U516 pseudouridine synthase
 
  
cpxAsensory histidine kinase in two-component regulato 
 
 
ddlBD-alanine:D-alanine ligase
 
  
accAacetyl-CoA carboxylase, carboxytransferase, alpha
 
  
fabF3-oxoacyl-[acyl-carrier-protein] synthase II
 
  
rluE23S rRNA U2457 pseudouridine synthase
 
  
xseAexonuclease VII, large subunit
 
  
recRgap repair protein
 
  
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
  
ddlAD-alanine-D-alanine ligase A
 
  
mrdAtranspeptidase involved in peptidoglycan synthesis
 
  
usgpredicted semialdehyde dehydrogenase
 
  
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
  
fabH3-oxoacyl-[acyl-carrier-protein] synthase III
 
  
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p
 
  
xseBexonuclease VII small subunit
 
  
radADNA repair protein
 
  
recGATP-dependent DNA helicase
 
  
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
  
mrdBcell wall shape-determining protein
 
  
rluF23S rRNA U2604 pseudouridine synthase
 
  
accCacetyl-CoA carboxylase, biotin carboxylase subunit
 
  
rluB23S rRNA pseudouridylate synthase
 
  
mfdtranscription-repair coupling factor
 
  
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
  
priAPrimosome factor n' (replication factor Y)
 
  
ftsWintegral membrane protein involved in stabilizing
 
  
recNrecombination and repair protein
 
  
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
  
fabB3-oxoacyl-[acyl-carrier-protein] synthase I
 
  
murCUDP-N-acetylmuramate:L-alanine ligase
 
  
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
  
ftsItranspeptidase involved in septal peptidoglycan sy
 
  
kdpDfused sensory histidine kinase in two-component re  
 
arcBaerobic respiration control sensor histidine prote  
 
adrAdiguanylate cyclase for cellulose, biofilm, motili  
 
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re  
 
yhjKpredicted diguanylate cyclase  
 
creCsensory histidine kinase in two-component regulato  
 
rcsChybrid sensory kinase in two-component regulatory   
 
ydaMdiguanylate cyclase, csgD regulator  
 
yeaPdiguanylate cyclase  
 
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m  
 
yegEpredicted diguanylate cyclase, GGDEF domain signal  
 
phoRsensory histidine kinase in two-component regulato  
 
yedVpredicted sensory kinase in two-component regulato  
 
ydeHdiguanylate cyclase, required for pgaD induction  
 
barAhybrid sensory histidine kinase, in two-component   
 
zraSsensory histidine kinase in two-component regulato  
 
yfiNpredicted diguanylate cyclase  
 
glrKSensor protein kinase regulating glmY sRNA in two-  
 
yneFpredicted diguanylate cyclase  
 
cusSsensory histidine kinase in two-component regulato  
 
dosCdiguanylate cyclase  
 
atoSsensory histidine kinase in two-component regulato  
 
rstBsensory histidine kinase in two-component regulato  
 
evgShybrid sensory histidine kinase in two-component r  
 
ycdTdiguanylate cyclase  
 
yedQpredicted diguanylate cyclase  
 
glnLsensory histidine kinase in two-component regulato  
 
yeaJpredicted diguanylate cyclase  
 
torShybrid sensory histidine kinase in two-component r  
 
yliFpredicted diguanylate cyclase  
 
baeSsensory histidine kinase in two-component regulato  
 
yeaIpredicted diguanylate cyclase  
 
basSsensory histidine kinase in two-component regulato