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Functional Status	Green (experimental evidence, uncurated)
GO terms	BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA BP: GO:0006350 : transcription : IEP MF: GO:0016563 : transcription activator activity : IDA BP: GO:0043193 : positive regulation of gene-specific transcription : ISS MF: GO:0016564 : transcription repressor activity : IDA MF: GO:0016566 : specific transcriptional repressor activity : IDA CC: GO:0005737 : cytoplasm : IEA MF: GO:0000156 : two-component response regulator activity : IEA MF: GO:0016564 : transcription repressor activity : IEP MF: GO:0016563 : transcription activator activity : ISS BP: GO:0043193 : positive regulation of gene-specific transcription : IDA BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA MF: GO:0003700 : transcription factor activity : ISS BP: GO:0032582 : negative regulation of gene-specific transcription : IDA MF: GO:0005515 : protein binding : IPI BP: GO:0006350 : transcription : IEA MF: GO:0003677 : DNA binding : IEA MF: GO:0016563 : transcription activator activity : IEP MF: GO:0016566 : specific transcriptional repressor activity : ISS BP: GO:0006350 : transcription : IDA BP: GO:0045449 : regulation of transcription : IEA MF: GO:0003700 : transcription factor activity : IDA BP: GO:0032582 : negative regulation of gene-specific transcription : ISS
Domain Structure from CDD	trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and a response regulator. The former autophosphorylates in a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. The C-terminal effector domain contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunite of RNA polymerase..... (More) REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; contains a phosphoacceptor site that is phosphorylated by histidine kinase homologs; usually found N-terminal to a DNA binding effector domain; forms homodimers.... (More) PRK10955: DNA-binding transcriptional regulator CpxR; Provisional See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam	Trans_reg_C Response_reg H See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details)	[Download ] CKO_03088 , cpxR (50) , cpxR1 , cpxR2 (2) , EcolC_4105 , ECP_4122 , ECs4838 , ECSE_4201 , Ent638_4060 , ESA_04123 , NT01EI_3811 , SARI_03585 , SG2180 , SPAB_05031 , Spro_4810 , SSPA3630 , YPA_3469 , YPDSF_3832 , YPK_4132 , YPN_3777 , YPTS_0071

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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com

rsuA 16S rRNA U516 pseudouridine synthase       cpxA sensory histidine kinase in two-component regulato       ddlB D-alanine:D-alanine ligase       accA acetyl-CoA carboxylase, carboxytransferase, alpha       fabF 3-oxoacyl-[acyl-carrier-protein] synthase II       rluE 23S rRNA U2457 pseudouridine synthase       xseA exonuclease VII, large subunit       recR gap repair protein       mpl UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes       polA fused DNA polymerase I 5'->3' polymerase/3'->5' ex       ddlA D-alanine-D-alanine ligase A       mrdA transpeptidase involved in peptidoglycan synthesis       usg predicted semialdehyde dehydrogenase       clpX ATPase and specificity subunit of ClpX-ClpP ATP-de       fabH 3-oxoacyl-[acyl-carrier-protein] synthase III       folK 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p       xseB exonuclease VII small subunit       radA DNA repair protein       recG ATP-dependent DNA helicase       glmU fused N-acetyl glucosamine-1-phosphate uridyltrans       mrdB cell wall shape-determining protein       rluF 23S rRNA U2604 pseudouridine synthase       accC acetyl-CoA carboxylase, biotin carboxylase subunit       rluB 23S rRNA pseudouridylate synthase       mfd transcription-repair coupling factor       murB UDP-N-acetylenolpyruvoylglucosamine reductase, FAD       priA Primosome factor n' (replication factor Y)       ftsW integral membrane protein involved in stabilizing       recN recombination and repair protein       murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase       fabB 3-oxoacyl-[acyl-carrier-protein] synthase I       murC UDP-N-acetylmuramate:L-alanine ligase       clpP proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP       ftsI transpeptidase involved in septal peptidoglycan sy       kdpD fused sensory histidine kinase in two-component re       arcB aerobic respiration control sensor histidine prote       adrA diguanylate cyclase for cellulose, biofilm, motili       dosP oxygen sensor, c-di-GMP phosphodiesterase, heme-re       yhjK predicted diguanylate cyclase       creC sensory histidine kinase in two-component regulato       rcsC hybrid sensory kinase in two-component regulatory       ydaM diguanylate cyclase, csgD regulator       yeaP diguanylate cyclase       gmr cyclic-di-GMP phosphodiesterase; csgD regulator; m       yegE predicted diguanylate cyclase, GGDEF domain signal       phoR sensory histidine kinase in two-component regulato       yedV predicted sensory kinase in two-component regulato       ydeH diguanylate cyclase, required for pgaD induction       barA hybrid sensory histidine kinase, in two-component       zraS sensory histidine kinase in two-component regulato       yfiN predicted diguanylate cyclase       glrK Sensor protein kinase regulating glmY sRNA in two-       yneF predicted diguanylate cyclase       cusS sensory histidine kinase in two-component regulato       dosC diguanylate cyclase       atoS sensory histidine kinase in two-component regulato       rstB sensory histidine kinase in two-component regulato       evgS hybrid sensory histidine kinase in two-component r       ycdT diguanylate cyclase       yedQ predicted diguanylate cyclase       glnL sensory histidine kinase in two-component regulato       yeaJ predicted diguanylate cyclase       torS hybrid sensory histidine kinase in two-component r       yliF predicted diguanylate cyclase       baeS sensory histidine kinase in two-component regulato       yeaI predicted diguanylate cyclase       basS sensory histidine kinase in two-component regulato

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