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Gene priA from Escherichia coli str. K-12 substr. MG1655: Primosome factor n' (replication factor Y)
Member of NCBI Protein Clusters PRK05580(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948426
UniProtKB accession
RefSeq Protein accession NP_418370.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: priA
  • locus tag: b3935
  • aliases: ECK3927, JW3906, srgA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction primosome assembly protein PriA
Source References Functional description
GSDB Under Review primosomal protein N' (source organism: Escherichia coli K12; strain specific ID: NCBI_TaxID=83333)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0008026 : ATP-dependent helicase activity : IEA
  • BP: GO:0006269 : DNA replication, synthesis of RNA primer : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • MF: GO:0008270 : zinc ion binding : IEA
  • MF: GO:0005515 : protein binding : IPI
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0004386 : helicase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • CC: GO:0005658 : alpha DNA polymerase:primase complex : IEA
Domain Structure from CDD
  • DEXDc: DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domai.... (More)
  • PRK05580: primosome assembly protein PriA; Validated
  • DEXDc: N/A. This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03059 , EcolC_4083 , ECP_4144 , ECs4862 , ECSE_4224 , Ent638_4038 , ESA_03825 , priA (36) , SARI_03561 , SeAg_B4341 , SeD_A4495 , SeHA_C4427 , SeSA_A4311 , SNSL254_A4425 , SPAB_05073 , SSPA3665
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
prfBpeptide chain release factor RF-2
 
baeRDNA-binding response regulator in two-component re
 
ftsWintegral membrane protein involved in stabilizing
 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho
 
rimM16S rRNA processing protein
 
qseBquorum sensing DNA-binding response regulator in t
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
yajCSecYEG protein translocase auxillary subunit
 
ddlAD-alanine-D-alanine ligase A
 
rpsA30S ribosomal subunit protein S1
 
kdpEDNA-binding response regulator in two-component re
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
yggWpredicted oxidoreductase, HemN family
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
pcnBpoly(A) polymerase I
 
secGpreprotein translocase membrane subunit
 
mrdAtranspeptidase involved in peptidoglycan synthesis
 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
 
murGN-acetylglucosaminyl transferase
 
murCUDP-N-acetylmuramate:L-alanine ligase
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
radADNA repair protein
 
phoBDNA-binding response regulator in two-component re
 
ompRDNA-binding response regulator in two-component re
 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
 
rluB23S rRNA pseudouridylate synthase
 
ygeRnovel lipoprotein, function unknown
 
basRDNA-binding response regulator in two-component re
 
yaeJconserved protein
 
phoPDNA-binding response regulator in two-component re
 
mfdtranscription-repair coupling factor
 
yebApredicted peptidase
 
pnppolynucleotide phosphorylase/polyadenylase
 
recGATP-dependent DNA helicase
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
torRDNA-binding response regulator in two-component re
 
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-dia
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
rluF23S rRNA U2604 pseudouridine synthase
 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
 
creBDNA-binding response regulator in two-component re
 
yedWpredicted DNA-binding response regulator in two-co
 
nlpDnovel lipoprotein, function unknown
 
ftsItranspeptidase involved in septal peptidoglycan sy
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
rsuA16S rRNA U516 pseudouridine synthase
 
ddlBD-alanine:D-alanine ligase
 
arcADNA-binding response regulator in two-component re
 
cpxRDNA-binding response regulator in two-component re
 
rluE23S rRNA U2457 pseudouridine synthase
 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t
 
mrdBcell wall shape-determining protein
 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
 
cusRDNA-binding response regulator in two-component re
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(candidate essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(not essential)