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Gene murB from Escherichia coli str. K-12 substr. MG1655: UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding
Member of NCBI Protein Clusters PRK00046(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948470
UniProtKB accession
RefSeq Protein accession NP_418403.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: murB
  • locus tag: b3972
  • aliases: ECK3964, JW3940, yijB
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
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Source Predicted function(s)
NCBI Protein Cluster Prediction UDP-N-acetylenolpyruvoylglucosamine reductase
Source References Functional description
[PMID: 1311302]
[PMID: 8448160]
[PMID: 8805513]
[PMID: 9020778]
[PMID: 9150408]
UDP-N-acetylenolpyruvoylglucosamine reductase (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • MF: GO:0008762 : UDP-N-acetylmuramate dehydrogenase activity : IEA
  • CC: GO:0005737 : cytoplasm : IDA
  • MF: GO:0050660 : FAD binding : IEA
  • BP: GO:0008360 : regulation of cell shape : IMP
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • MF: GO:0050660 : FAD binding : IDA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IMP
  • BP: GO:0051301 : cell division : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
  • BP: GO:0007047 : cellular cell wall organization : IMP
  • MF: GO:0008762 : UDP-N-acetylmuramate dehydrogenase activity : IDA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0003824 : catalytic activity : IEA
Domain Structure from CDD
  • murB: UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional
  • FAD_binding_4: FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar.... (More)
  • MurB_C: UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain. Members of this family are UDP-N-acetylenolpyruvoylglu.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
murB (46)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
birAbifunctional biotin-[acetylCoA carboxylase] holoen
pnppolynucleotide phosphorylase/polyadenylase 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
torRDNA-binding response regulator in two-component re 
rluF23S rRNA U2604 pseudouridine synthase 
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent 
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho 
rimM16S rRNA processing protein 
qseBquorum sensing DNA-binding response regulator in t 
yedWpredicted DNA-binding response regulator in two-co 
nlpDnovel lipoprotein, function unknown 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
yajCSecYEG protein translocase auxillary subunit 
ddlAD-alanine-D-alanine ligase A 
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t 
mrdBcell wall shape-determining protein 
yggWpredicted oxidoreductase, HemN family 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion 
pcnBpoly(A) polymerase I 
secGpreprotein translocase membrane subunit 
prfBpeptide chain release factor RF-2 
baeRDNA-binding response regulator in two-component re 
ftsWintegral membrane protein involved in stabilizing  
murCUDP-N-acetylmuramate:L-alanine ligase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
radADNA repair protein 
rluB23S rRNA pseudouridylate synthase 
ygeRnovel lipoprotein, function unknown 
basRDNA-binding response regulator in two-component re 
yaeJconserved protein 
phoPDNA-binding response regulator in two-component re 
mfdtranscription-repair coupling factor 
yebApredicted peptidase 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
rpsA30S ribosomal subunit protein S1 
kdpEDNA-binding response regulator in two-component re 
creBDNA-binding response regulator in two-component re 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
priAPrimosome factor n' (replication factor Y) 
ddlBD-alanine:D-alanine ligase 
arcADNA-binding response regulator in two-component re 
mrdAtranspeptidase involved in peptidoglycan synthesis 
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de 
murGN-acetylglucosaminyl transferase 
cpxRDNA-binding response regulator in two-component re 
phoBDNA-binding response regulator in two-component re 
ompRDNA-binding response regulator in two-component re 
rluE23S rRNA U2457 pseudouridine synthase 
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase 
cusRDNA-binding response regulator in two-component re 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: UAPGR

UDP-N-acetylenolpyruvoylglucosamine reductase
h[c] + nadph[c] + uaccg[c] -> nadp[c] + uamr[c]
Cell Envelope Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 13129938
(not essential)
PMID: 17700540
(candidate essential)
PMID: 20029369
(candidate essential)