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Gene mpl from Escherichia coli str. K-12 substr. MG1655: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
Member of NCBI Protein Clusters CLSK880878(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948752
UniProtKB accession
RefSeq Protein accession NP_418654.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: mpl
  • locus tag: b4233
  • aliases: ECK4228, JW4192, tpl, yjfG
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG12440
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
Source References Functional description
[PMID: 8808921]
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (source organism: Escherichia coli (strain K12).; strain specific ID: )
Functional Status greenGreen (experimental evidence, uncurated)
EC number 6.3.2.- (See reaction via BRENDA)) (Source: NCBI RefSeq)
GO terms
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • MF: GO:0016881 : acid-amino acid ligase activity : IDA
  • CC: GO:0005737 : cytoplasm : IDA
  • CC: GO:0005576 : extracellular region : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • BP: GO:0051301 : cell division : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0005488 : binding : IEA
  • MF: GO:0005515 : protein binding : IPI
Domain Structure from CDD
  • mpl: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase. Alternate name: murein tripeptide ligase
  • Mur_ligase_C: Mur ligase family, glutamate ligase domain. This family contains a number of related ligase enzymes which have EC number.... (More)
  • Mur_ligase_M: Mur ligase middle domain.
  • Mur_ligase: Mur ligase family, catalytic domain. This family contains a number of related ligase enzymes which have EC numbers 6.3.2.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
CKO_03597 , EcolC_3778 , ECP_4482 , ECs5210 , ECSE_4538 , Ent638_0419 , ESA_00241 , mpl (39) , SARI_03211 , SPAB_05558 , Spro_0465 , y0665 , yjfG (9) , YPA_0069 , YPDSF_3568 , YPK_3765 , YPN_3263 , YPTS_0487
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
domain fusion
rluB23S rRNA pseudouridylate synthase
ygeRnovel lipoprotein, function unknown
basRDNA-binding response regulator in two-component re
yaeJconserved protein
phoPDNA-binding response regulator in two-component re
mfdtranscription-repair coupling factor
yebApredicted peptidase
rluF23S rRNA U2604 pseudouridine synthase
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
murGN-acetylglucosaminyl transferase
recGATP-dependent DNA helicase
creBDNA-binding response regulator in two-component re
ftsItranspeptidase involved in septal peptidoglycan sy
rsuA16S rRNA U516 pseudouridine synthase
priAPrimosome factor n' (replication factor Y)
ddlBD-alanine:D-alanine ligase
ompRDNA-binding response regulator in two-component re
arcADNA-binding response regulator in two-component re
rsmD16S rRNA m(2)G966 methyltransferase, SAM-dependent
cpxRDNA-binding response regulator in two-component re
phoBDNA-binding response regulator in two-component re
torRDNA-binding response regulator in two-component re
hemNcoproporphyrinogen III oxidase, SAM and NAD(P)H de
rluE23S rRNA U2457 pseudouridine synthase
cusRDNA-binding response regulator in two-component re
yedWpredicted DNA-binding response regulator in two-co
pnppolynucleotide phosphorylase/polyadenylase
nlpDnovel lipoprotein, function unknown
ccafused tRNA nucleotidyl transferase/2'3'-cyclic pho
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
rimM16S rRNA processing protein
qseBquorum sensing DNA-binding response regulator in t
miaAdelta(2)-isopentenylpyrophosphate tRNA-adenosine t
mrdBcell wall shape-determining protein
rstAmulticopy supressor of yjeE, yeaZ or ygjD deletion
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
yajCSecYEG protein translocase auxillary subunit
prfBpeptide chain release factor RF-2
ddlAD-alanine-D-alanine ligase A
baeRDNA-binding response regulator in two-component re
ftsWintegral membrane protein involved in stabilizing
yggWpredicted oxidoreductase, HemN family
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
pcnBpoly(A) polymerase I
mrdAtranspeptidase involved in peptidoglycan synthesis
secGpreprotein translocase membrane subunit
murDUDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
rpsA30S ribosomal subunit protein S1
kdpEDNA-binding response regulator in two-component re
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
radADNA repair protein