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Gene arcA from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with ArcB or CpxA
Member of NCBI Protein Clusters PRK11173(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948874
UniProtKB accession
RefSeq Protein accession NP_418818.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: arcA
  • locus tag: b4401
  • aliases: ECK4393, JW4364, cpxC, dye, fexA, msp, seg, sfrA
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB: 1XHE 1XHF
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG10061
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction two-component response regulator
Source References Functional description
GSDB
[PMID: 9298646]
[PMID: 7565118]
Aerobic respiration control protein ArcA (source organism: Escherichia coli (strain K12).; strain specific ID: K12 / EMG2)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IDA
  • MF: GO:0016564 : transcription repressor activity : ISS
  • CC: GO:0005622 : intracellular : IEA
  • MF: GO:0016563 : transcription activator activity : IDA
  • BP: GO:0045892 : negative regulation of transcription, DNA-dependent : ISS
  • MF: GO:0016564 : transcription repressor activity : IDA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • MF: GO:0016563 : transcription activator activity : ISS
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IDA
  • MF: GO:0003700 : transcription factor activity : ISS
  • BP: GO:0045893 : positive regulation of transcription, DNA-dependent : ISS
  • BP: GO:0045892 : negative regulation of transcription, DNA-dependent : IDA
  • MF: GO:0005515 : protein binding : IPI
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0006350 : transcription : IDA
  • BP: GO:0045449 : regulation of transcription : IEA
  • MF: GO:0003700 : transcription factor activity : IDA
  • BP: GO:0045893 : positive regulation of transcription, DNA-dependent : IDA
  • MF: GO:0000156 : two-component response regulator activity : IDA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK11173: two-component response regulator; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
APP7_0048 , arcA (57) , arcA-1 , Asuc_0879 , CKO_03387 , EcolC_3655 , ECP_4787 , ECs5359 , ECSE_4677 , Ent638_0562 , ESA_03337 , fexA , NT01EI_0655 , ompR , PBPRA0547 , Sama_0601 , SARI_02992 , Sbal_0786 , Sbal195_3842 , Sbal223_3660 , Sfri_0533 , SG0403 , Shal_0786 , Shew_0777 , Shew185_3719 , Shewana3_0650 , Shewmr4_0651 , Shewmr7_3371 , SPAB_05779 , Spea_0733 , Spro_0681 , Sputcn32_0678 , Sputw3181_3493 , Ssed_0815 , SSPA4092 , Swoo_3762 , swp_4347 , VC2368 , VCD_001981 , VFMJ11_2226 , VIBHAR_00933 , VP0489 , VV0646 , VV1_0548 , YPA_4049 , YpAngola_A0811 , YPDSF_3176 , YPK_3606 , YPN_0329 , YpsIP31758_3478 , YPTS_0624
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 phylogenetic profile
domain fusion
rluE23S rRNA U2457 pseudouridine synthase
 
 
xseAexonuclease VII, large subunit
 
 
fabF3-oxoacyl-[acyl-carrier-protein] synthase II
 
 
recRgap repair protein
 
 
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-mes
 
 
accAacetyl-CoA carboxylase, carboxytransferase, alpha
 
 
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex
 
 
ddlAD-alanine-D-alanine ligase A
 
 
mrdAtranspeptidase involved in peptidoglycan synthesis
 
 
usgpredicted semialdehyde dehydrogenase
 
 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de
 
 
mrdBcell wall shape-determining protein
 
 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III
 
 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p
 
 
xseBexonuclease VII small subunit
 
 
ftsWintegral membrane protein involved in stabilizing
 
 
radADNA repair protein
 
 
recGATP-dependent DNA helicase
 
 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans
 
 
rluB23S rRNA pseudouridylate synthase
 
 
rluF23S rRNA U2604 pseudouridine synthase
 
 
accCacetyl-CoA carboxylase, biotin carboxylase subunit
 
 
mfdtranscription-repair coupling factor
 
 
recNrecombination and repair protein
 
 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase
 
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD
 
 
priAPrimosome factor n' (replication factor Y)
 
 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I
 
 
murCUDP-N-acetylmuramate:L-alanine ligase
 
 
ftsItranspeptidase involved in septal peptidoglycan sy
 
 
rsuA16S rRNA U516 pseudouridine synthase
 
 
ddlBD-alanine:D-alanine ligase
 
 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP
 
 
torShybrid sensory histidine kinase in two-component r 
 
ylaBpredicted cyclic-di-GMP phosphodiesterase 
 
yliFpredicted diguanylate cyclase 
 
baeSsensory histidine kinase in two-component regulato 
 
yeaIpredicted diguanylate cyclase 
 
yeaPdiguanylate cyclase 
 
ydaMdiguanylate cyclase, csgD regulator 
 
kdpDfused sensory histidine kinase in two-component re 
 
barAhybrid sensory histidine kinase, in two-component  
 
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m 
 
yegEpredicted diguanylate cyclase, GGDEF domain signal 
 
phoRsensory histidine kinase in two-component regulato 
 
yneFpredicted diguanylate cyclase 
 
yliEpredicted cyclic-di-GMP phosphodiesterase, inner m 
 
cusSsensory histidine kinase in two-component regulato 
 
yfeApredicted diguanylate cyclase 
 
cheAfused chemotactic sensory histidine kinase in two- 
 
dosCdiguanylate cyclase 
 
ycgGpredicted cyclic-di-GMP phosphodiesterase 
 
aerfused signal transducer for aerotaxis sensory comp 
 
yedVpredicted sensory kinase in two-component regulato 
 
adrBpredicted phosphodiesterase 
 
ydeHdiguanylate cyclase, required for pgaD induction 
 
cpxAsensory histidine kinase in two-component regulato 
 
zraSsensory histidine kinase in two-component regulato 
 
yfiNpredicted diguanylate cyclase 
 
glrKSensor protein kinase regulating glmY sRNA in two- 
 
yahAc-di-GMP-specific phosphodiesterase 
 
glnLsensory histidine kinase in two-component regulato 
 
ypdApredicted sensory kinase in two-component system w 
 
yeaJpredicted diguanylate cyclase 
 
basSsensory histidine kinase in two-component regulato 
 
atoSsensory histidine kinase in two-component regulato 
 
yfgFinner membrane protein, predicted c-di-GMP dual ac 
 
rstBsensory histidine kinase in two-component regulato 
 
rtnresistance protein for phages lambda and N4, when  
 
evgShybrid sensory histidine kinase in two-component r 
 
yehUpredicted sensory kinase in two-component system w 
 
arcBaerobic respiration control sensor histidine prote 
 
ycdTdiguanylate cyclase 
 
yedQpredicted diguanylate cyclase 
 
adrAdiguanylate cyclase for cellulose, biofilm, motili 
 
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re 
 
yhjKpredicted diguanylate cyclase 
 
yjcCpredicted cyclic-di-GMP phosphodiesterase 
 
creCsensory histidine kinase in two-component regulato 
 
rcsChybrid sensory kinase in two-component regulatory