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Gene creB from Escherichia coli str. K-12 substr. MG1655: DNA-binding response regulator in two-component regulatory system with CreC
Member of NCBI Protein Clusters PRK11083(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 948922
UniProtKB accession
RefSeq Protein accession NP_418815.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: creB
  • locus tag: b4398
  • aliases: ECK4390, JW4361, ORF2, yjjE
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: EG11218
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA-binding response regulator CreB
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green regX3 from Mycobacterium smegmatis str. MC2 155
(%_identity=37.95; E_val=3e-38; BitScore=153.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green phoP from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

to see the rest 51 genes click here
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006350 : transcription : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
Domain Structure from CDD
  • trans_reg_C: Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • PRK11083: DNA-binding response regulator CreB; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 gene neighbourhoods
phylogenetic profile
domain fusion
creCsensory histidine kinase in two-component regulato
rluE23S rRNA U2457 pseudouridine synthase 
mrdBcell wall shape-determining protein 
xseAexonuclease VII, large subunit 
recRgap repair protein 
ftsWintegral membrane protein involved in stabilizing  
fabF3-oxoacyl-[acyl-carrier-protein] synthase II 
mrdAtranspeptidase involved in peptidoglycan synthesis 
accAacetyl-CoA carboxylase, carboxytransferase, alpha  
polAfused DNA polymerase I 5'->3' polymerase/3'->5' ex 
ddlAD-alanine-D-alanine ligase A 
fabH3-oxoacyl-[acyl-carrier-protein] synthase III 
usgpredicted semialdehyde dehydrogenase 
clpXATPase and specificity subunit of ClpX-ClpP ATP-de 
recGATP-dependent DNA helicase 
glmUfused N-acetyl glucosamine-1-phosphate uridyltrans 
folK2-amino-4-hydroxy-6-hydroxymethyldihyropteridine p 
rluF23S rRNA U2604 pseudouridine synthase 
accCacetyl-CoA carboxylase, biotin carboxylase subunit 
xseBexonuclease VII small subunit 
radADNA repair protein 
murBUDP-N-acetylenolpyruvoylglucosamine reductase, FAD 
rluB23S rRNA pseudouridylate synthase 
priAPrimosome factor n' (replication factor Y) 
mfdtranscription-repair coupling factor 
murCUDP-N-acetylmuramate:L-alanine ligase 
recNrecombination and repair protein 
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase 
clpPproteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP 
fabB3-oxoacyl-[acyl-carrier-protein] synthase I 
ftsItranspeptidase involved in septal peptidoglycan sy 
rsuA16S rRNA U516 pseudouridine synthase 
ddlBD-alanine:D-alanine ligase 
adrAdiguanylate cyclase for cellulose, biofilm, motili  
dosPoxygen sensor, c-di-GMP phosphodiesterase, heme-re  
yhjKpredicted diguanylate cyclase  
yjcCpredicted cyclic-di-GMP phosphodiesterase  
rcsChybrid sensory kinase in two-component regulatory   
rtcRsigma 54-dependent transcriptional regulator of rt  
torShybrid sensory histidine kinase in two-component r  
ylaBpredicted cyclic-di-GMP phosphodiesterase  
yliFpredicted diguanylate cyclase  
baeSsensory histidine kinase in two-component regulato  
yeaIpredicted diguanylate cyclase  
prpRpropionate catabolism operon regulatory protein  
yeaPdiguanylate cyclase  
ydaMdiguanylate cyclase, csgD regulator  
kdpDfused sensory histidine kinase in two-component re  
fhlADNA-binding transcriptional activator  
pspFDNA-binding transcriptional activator  
barAhybrid sensory histidine kinase, in two-component   
norRAnaerobic nitric oxide reductase DNA-binding trans  
gmrcyclic-di-GMP phosphodiesterase; csgD regulator; m  
yegEpredicted diguanylate cyclase, GGDEF domain signal  
phoRsensory histidine kinase in two-component regulato  
yneFpredicted diguanylate cyclase  
yliEpredicted cyclic-di-GMP phosphodiesterase, inner m  
cusSsensory histidine kinase in two-component regulato  
yfeApredicted diguanylate cyclase  
dosCdiguanylate cyclase  
ycgGpredicted cyclic-di-GMP phosphodiesterase  
aerfused signal transducer for aerotaxis sensory comp  
yedVpredicted sensory kinase in two-component regulato  
adrBpredicted phosphodiesterase  
ydeHdiguanylate cyclase, required for pgaD induction  
cpxAsensory histidine kinase in two-component regulato  
zraSsensory histidine kinase in two-component regulato  
yfiNpredicted diguanylate cyclase  
glrKSensor protein kinase regulating glmY sRNA in two-  
yahAc-di-GMP-specific phosphodiesterase  
glnLsensory histidine kinase in two-component regulato  
yeaJpredicted diguanylate cyclase  
ygeVpredicted DNA-binding transcriptional regulator  
hyfRDNA-binding transcriptional activator, formate sen  
basSsensory histidine kinase in two-component regulato  
atoSsensory histidine kinase in two-component regulato  
tyrRDNA-binding transcriptional dual regulator, tyrosi  
yfgFinner membrane protein, predicted c-di-GMP dual ac  
rstBsensory histidine kinase in two-component regulato  
rtnresistance protein for phages lambda and N4, when   
evgShybrid sensory histidine kinase in two-component r  
arcBaerobic respiration control sensor histidine prote  
ycdTdiguanylate cyclase  
yedQpredicted diguanylate cyclase