Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene ygfU from Escherichia coli str. K-12 substr. MG1655: predicted transporter
Member of NCBI Protein Clusters CLSK880522(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 949017
UniProtKB accession
RefSeq Protein accession NP_417364.2 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ygfU
  • locus tag: b2888
  • aliases: ECK2883, JW5470
Organism Escherichia coli str. K-12 substr. MG1655 (NCBI TaxID: 511145)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc: G7507
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction putative permease
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green pucK from Bacillus subtilis subsp. subtilis str. 168
(%_identity=41.88; E_val=6e-86; BitScore=313.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green xanQ from Escherichia coli str. K-12 substr. MG1655

to see the rest 9 genes click here
GO terms
  • MF: GO:0005215 : transporter activity : IEA
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0055085 : transmembrane transport : IEA
  • BP: GO:0006810 : transport : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
Domain Structure from CDD
  • Xan_ur_permease: Permease family. putative purine permease YbbY; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
 phylogenetic profile
domain fusion
ygbIpredicted transcriptional regulator, DeoR family
srlRDNA-bindng transcriptional repressor
glpRDNA-binding transcriptional repressor
yihWpredicted DNA-binding transcriptional regulator
ulaRtranscriptional tepressor for the L-ascorbate util
yciTglobal regulator of transcription; DeoR family
ydjFpredicted DNA-binding transcriptional regulator
fucRDNA-binding transcriptional activator
agaRDNA-binding transcriptional repressor of the aga r
nupGnucleoside transporter
sgcRKpLE2 phage-like element; predicted DNA-binding tr
yfeApredicted diguanylate cyclase